The many ways of osteoclast activation

The Journal of Clinical Investigation
Joseph Lorenzo

Abstract

Osteoclasts are the cells responsible for bone resorption, a process that is essential for the maintenance of healthy bones. Bone diseases, such as osteoporosis, which are characterized by high rates of bone resorption and loss of bone mass, may benefit from treatments that inhibit osteoclast formation and/or function. The RANKL/RANK pathway is critical for both osteoclast formation and function, and these effects are thought to be mediated by the transcription factor nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). In this issue of the JCI, Bae et al. challenge the convention that NFATc1 is the sole critical regulator of RANKL/RANK-dependent osteoclast activation. Specifically, the authors show that MYC drives metabolic reprogramming in osteoclasts and that MYC induces estrogen receptor-related receptor α (ERRα) to regulate osteoclastogenesis. Importantly, both loss of MYC and pharmacological inhibition of ERRα attenuated bone loss in a mouse model of osteoporosis. Together, the results of this study suggest that the MYC/ERRα pathway should be further explored as a drug target for bone diseases.

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Citations

Jul 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuang YangPing Zhang
Dec 31, 2019·Journal of Cellular Biochemistry·Mingwei HuangHongcheng Ding
Aug 24, 2017·Journal of Cellular Physiology·Gengyang ShenXiaobing Jiang
Aug 14, 2020·Journal of Cellular and Molecular Medicine·Zhi QianBaoqing Yu
Mar 1, 2019·Journal of Cellular Physiology·Kai LiJiake Xu
Oct 22, 2020·Acta Biochimica Et Biophysica Sinica·Huaqiang TaoDechun Geng
Dec 9, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaoli ZhaoZhen Wang
May 11, 2020·International Immunopharmacology·Jinwei LuRongxin He
Dec 29, 2020·Research in Veterinary Science·Naixi YangRuili Zhang
Mar 1, 2021·Journal of Periodontal Research·Natalie Aparecida Rodrigues FernandesMorgana Rodrigues Guimarães-Stabili
Apr 22, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zhencheng XiongChi Zhang
Jun 5, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cecilia Gotti, Francesco Clementi
Jun 7, 2021·International Immunopharmacology·Peiyao WuLei Zhao
Jun 19, 2021·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Ute NazetChristian Kirschneck

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Methods Mentioned

BETA
ChIP

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