The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness

Current Drug Targets. CNS and Neurological Disorders
A Zine, T R van de Water

Abstract

The c-Jun N-terminal kinases (JNKs) are also called stress activated protein kinases (SAPKs) and are members of the family of mitogen activated protein kinases (MAPKs). While the functions of the JNKs under physiological conditions are diverse and not completely understood, there is increasing evidence that JNKs are potent effectors of apoptosis of oxidative stress-damaged cells in both the brain and the mammalian inner ear following a trauma. The activation of the inducible transcription factor c-Jun by N-terminal phosphorylation is a central event in JNK-mediated apoptosis of oxidative stress-damaged auditory hair cells following exposure to either acoustic trauma or a toxic level of an aminoglycoside antibiotic and also the apoptosis of auditory neurons as a consequence of a loss of the trophic support provided by the auditory hair cells. In this review, we summarise what is known about the expression and activation of G-proteins, JNKs, c-Jun and c-Fos under oxidative stress conditions within the mammalian cochlea. A particular focus is put on a new peptide conjugate that is a promising protective agent(s) and pharmacological strategies for preventing cochlear damage induced by both acoustic trauma and aminoglycoside ototoxi...Continue Reading

Citations

Jan 1, 2010·Cochlear Implants International·Adrien A EshraghiThomas R Van De Water
Jan 23, 2008·HNO·S Pfannenstiel, M Praetorius
Feb 26, 2009·Journal of the Association for Research in Otolaryngology : JARO·Henry C OuEdwin W Rubel
Oct 8, 2008·Apoptosis : an International Journal on Programmed Cell Death·Sherif F TadrosRobert D Frisina
Dec 29, 2012·Purinergic Signalling·Tania MartiáñezAlejandro Gella
Nov 29, 2011·International Journal of Otolaryngology·M E HuthA G Cheng
Mar 19, 2011·Journal of Neurovirology·Scott J SchachteleJames R Lokensgard
Apr 30, 2011·Acta Oto-laryngologica·Min XiongJian Wang
Feb 24, 2016·Frontiers in Cellular Neuroscience·Chengfu CaiYingzi He
Aug 5, 2009·Hearing Research·Marlies KnipperMarcus Müller
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Nov 1, 2005·Ecology Letters·Andrew Balmford, William Bond
Mar 28, 2007·Journal of Neuroscience Research·Linda R WhiteJan O Aasly
Mar 22, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Adrien A Eshraghi, Thomas R Van de Water
Jul 28, 2011·Journal of Cellular Physiology·Marina Di DomenicoEttore Cassandro
May 1, 2010·Journal of Communication Disorders·Seiji B Shibata, Yehoash Raphael
Jun 3, 2011·Acta Oto-laryngologica·Min XiongJian Wang
May 8, 2015·BioMed Research International·Alan M RobinsonClaus-Peter Richter
Feb 20, 2007·Biochimica Et Biophysica Acta·Gary L Johnson, Kazuhiro Nakamura
Nov 12, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Alan G ChengEdwin W Rubel
May 13, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mun Young ChangJun Ho Lee
Dec 2, 2017·International Forum of Allergy & Rhinology·Andrew J VictoresAndrew P Lane
Sep 16, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Adrien A Eshraghi
Jul 25, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Rodney C Diaz
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Pei-Xin TanYa-Wei Yuan
Jul 1, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Markus SuckfuellThomas Meyer
Dec 5, 2019·The Journal of the Acoustical Society of America·Gaëlle NaertColleen G Le Prell
Nov 20, 2016·Expert Opinion on Therapeutic Patents·Kim NguyenCharles E McKenna
Apr 28, 2007·Progress in Biophysics and Molecular Biology·Elissavet KardamiDavid C Spray
Jun 23, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Adrien A EshraghiThomas R Van De Water

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