The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7)

Regulatory Peptides
Marina C MuñozFernando Pablo Dominici

Abstract

Angiotensin (Ang)-(1-7) stimulates proteins belonging to the insulin signaling pathway and ameliorates the Ang II negative effects at this level. However, up to date, receptors involved and mechanisms behind these observations remain unknown. Accordingly, in the present study, we explored the in vivo effects of antagonism of the Ang-(1-7) specific Mas receptor on insulin signal transduction in rat insulin-target tissues. We evaluated the acute modulation of insulin-stimulated phosphorylation of Akt, GSK-3β (Glycogen synthase kinase-3β) and AS160 (Akt substrate of 160kDa) by Ang-(1-7) and/or Ang II in the presence and absence of the selective Mas receptor antagonist A-779 in insulin-target tissues of normal rats. Also using A-779, we determined whether the Mas receptor mediates the improvement of insulin sensitivity exerted by chronic Ang-(1-7) treatment in fructose-fed rats (FFR), a model of insulin resistance, dyslipidemia and mild hypertension. The two major findings of the present work are as follows; 1) Ang-(1-7) attenuates acute Ang II-mediated inhibition of insulin signaling components in normal rats via a Mas receptor-dependent mechanism; and 2). The Mas receptor appears to be involved in beneficial effects of Ang-(1-7) ...Continue Reading

References

Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
May 13, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·F FolliC R Kahn
Oct 27, 1999·Regulatory Peptides·M M GironacciC Peña
Mar 15, 2003·The Journal of Biological Chemistry·Hiroyuki SanoGustav E Lienhard
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenta OkadaMitsuru Adachi
Feb 18, 2005·Journal of Hypertension·Karin A M Jandeleit-DahmMark E Cooper
Jan 4, 2006·Diabetes/metabolism Research and Reviews·Licio A VellosoMario J A Saad
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Cullen M TaniguchiC Ronald Kahn
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jorge F GianiFernando P Dominici
Jun 22, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erik J Henriksen
Nov 7, 2007·Hypertension·Walkyria O SampaioRhian M Touyz
Nov 21, 2007·Diabetes·Sérgio Henrique S SantosRobson Augusto S Santos
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yehuda KamariEhud Grossman
Aug 13, 2008·Hypertension·Marco F Dias-PeixotoSilvia Guatimosim
Oct 16, 2008·The Journal of Biological Chemistry·Ronen ShemeshYossi Cohen
Oct 22, 2008·Molecular and Cellular Endocrinology·Christina LyngsøJakob L Hansen
Jan 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jorge F GianiFernando P Dominici
Mar 26, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Zhen TanHong Ma
Jun 15, 2011·Hypertension·Mariela M GironacciOscar A Carretero

❮ Previous
Next ❯

Citations

Oct 29, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sérgio H S SantosMichael Bader
Feb 5, 2013·Seminars in Nephrology·Christiane Rüster, Gunter Wolf
Oct 21, 2015·Acta Physiologica·O Echeverría-RodríguezR Villalobos-Molina
Jul 31, 2013·IUBMB Life·Kavaljit H ChhabraEric Lazartigues
Mar 13, 2015·Medicinal Research Reviews·Claudio Cabello-VerrugioFelipe Simon
Oct 9, 2014·Pflügers Archiv : European journal of physiology·Carla MenesesClaudio Cabello-Verrugio
Dec 20, 2012·Clinical Science·Danielle G Passos-SilvaRobson A S Santos
Jan 24, 2014·Clinical Science·Fernando P DominiciJorge F Giani
Jun 10, 2014·Molecular and Cellular Endocrinology·Xi CaoJin-Kui Yang
Sep 12, 2014·Histochemistry and Cell Biology·María Gabriela MoralesClaudio Cabello-Verrugio
Jul 31, 2013·PloS One·Eliete Dalla Corte FrantzCarlos Alberto Mandarim-de-Lacerda
Feb 17, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Claudio Cabello-VerrugioDominga Garcia
Oct 10, 2018·American Journal of Physiology. Endocrinology and Metabolism·Justin LoloiAmy C Arnold
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Jan 4, 2020·The FEBS Journal·Pyotr A Tyurin-KuzminVsevolod A Tkachuk
Sep 24, 2014·Pharmacological Reviews·Michael BaderRobson A Santos
Jul 25, 2018·Clinical Science·Eliete Dalla Corte FrantzAntonio Claudio Lucas Nobrega
Jul 6, 2019·Journal of Cellular and Molecular Medicine·Mark A Winslow, Stephanie E Hall
Feb 28, 2020·Journal of the Endocrine Society·Omar Echeverría-RodríguezRafael Villalobos-Molina
Aug 10, 2019·Oxidative Medicine and Cellular Longevity·Vivian Paulino FigueiredoAndréia Carvalho Alzamora
Nov 25, 2020·Clinical Science·Koichi YamamotoHiromi Rakugi
Jan 29, 2020·Heliyon·Daniel Massote MagalhãesAna Cristina Simões E Silva
Jul 3, 2021·Microorganisms·Mahnaz NorouziRavichandra Vemuri
May 23, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hatem M AbuohashishSalim S Al-Rejaie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.