The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis

The American Journal of Pathology
Stephen J Galli

Abstract

Mast cells and IgE are so inextricably linked to the pathology of allergic disorders, including fatal anaphylaxis, that it can be difficult to think of them in other contexts. Surely, we do not have mast cells and IgE so that we can eat a peanut and die! It is thought that mast cells and IgE and basophils (circulating granulocytes, whose functions partially overlap with those of mast cells) can contribute to host defense as components of adaptive T helper cell type 2 immune responses to helminths, ticks, and certain other parasites. Accordingly, it was suggested that allergies are misdirected type 2 immune responses in which IgE antibodies are produced against any of a broad variety of apparently harmless antigens. However, components of animal venoms also can sensitize individuals to develop severe IgE-associated allergic reactions, including fatal anaphylaxis, on subsequent venom exposure. Here, I describe evidence that mast cells can enhance innate host resistance to reptile or arthropod venoms during responses to an initial exposure to such venoms and that acquired type 2 immune responses, IgE antibodies, the high-affinity IgE receptor FcεRI, and mast cells can contribute toward acquired resistance in mice to the lethal eff...Continue Reading

References

Feb 1, 1977·Immunochemistry·A Prouvost-DanonA Abadie
Sep 1, 1979·Clinical Allergy·R JarischA Janitsch
Jul 1, 1976·Transplantation·D E Harrison, C M Astle
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·H F Dvorak
Jan 1, 1975·International Archives of Allergy and Applied Immunology·C C CharavejasarnC E Arbesman
Mar 1, 1991·The Quarterly Review of Biology·M Profet
Aug 1, 1990·International Journal for Parasitology·E B Steeves, J R Allen
Nov 1, 1987·The Journal of Allergy and Clinical Immunology·A A Wadee, A R Rabson
Jul 28, 1972·Science·E Habermann
Jan 1, 1974·Perspectives in Biology and Medicine·J H Stebbings
Mar 1, 1973·International Journal for Parasitology·J R Allen
Jan 1, 1974·International Archives of Allergy and Applied Immunology·C B Saelinger, R D Higginbotham
Nov 1, 1982·The Journal of Cell Biology·S J GalliH F Dvorak
Aug 4, 1994·Nature·H C OettgenP Leder
May 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·E KochvaZ Wollberg
Jun 8, 1999·Annual Review of Immunology·J P Kinet
Oct 8, 1999·The Journal of Clinical Investigation·H C Oettgen, R S Geha
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A R ReimersU R Müller
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Annila
Jan 30, 2002·The Journal of Biological Chemistry·Ana G C Neves-FerreiraGilberto B Domont
Jul 20, 2002·Current Opinion in Allergy and Clinical Immunology·Leonardo AntonicelliFloriano Bonifazi
Nov 5, 2002·Annual Review of Entomology·James E Childs, Christopher D Paddock
May 12, 2004·Advances in Immunology·Daniel B StetsonRichard M Locksley
Sep 14, 2004·Immunological Reviews·Fred D FinkelmanJoseph F Urban
Nov 16, 2004·Nature·Marcus MaurerStephen J Galli
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J WoltersG H Caughey
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Jun 30, 2005·Current Opinion in Allergy and Clinical Immunology·Ulrich R Müller
Aug 30, 2005·The American Journal of Pathology·Michele A GrimbaldestonStephen J Galli
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiaki Kawakami, Jiro Kitaura
Oct 4, 2005·Allergy·B M BilóUNKNOWN EAACI Interest Group on Insect Venom Hypersensitivity
Jul 29, 2006·Science·Martin MetzStephen J Galli
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahisa FurutaNaohiro Watanabe

❮ Previous
Next ❯

Citations

Jun 1, 2016·Frontiers in Cell and Developmental Biology·Ivana Halova, Petr Draber
Sep 1, 2016·Mediators of Inflammation·Edismauro Garcia Freitas FilhoMaria Célia Jamur
Mar 24, 2018·Immunotherapy·Wenming ZhangKari Nadeau
Nov 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·K Eyerich, S Eyerich
Oct 10, 2018·International Immunology·Akihiko MurataShin-Ichi Hayashi
Apr 25, 2019·International Journal of Molecular Sciences·Gilda VarricchiGianni Marone
Mar 25, 2020·Investigative Ophthalmology & Visual Science·Alessandra MiceraStefano Bonini
Jun 22, 2020·Immunological Reviews·James B WingShimon Sakaguchi
Oct 3, 2020·Tissue Engineering. Part a·Emily W OzpinarDonald O Freytes
Jul 25, 2019·Frontiers in Cellular Neuroscience·Gilda VarricchiGiuseppe Spadaro
Jul 5, 2018·Science Signaling·Iris K Madera-SalcedoUlrich Blank
Jun 14, 2019·Frontiers in Immunology·Erika Méndez-Enríquez, Jenny Hallgren
Aug 14, 2019·International Journal of Molecular Sciences·Edismauro Garcia Freitas FilhoMaria Célia Jamur
Oct 25, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenshiro MatsudaHiroshi Matsuda
Jan 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peng-Sheng FanYa Liu
Dec 29, 2020·Frontiers in Immunology·Cynthia KanagarathamHans C Oettgen
Nov 7, 2020·Parasitology Research·Banchob Sripa, Melissa R Haswell
Nov 24, 2020·Allergo Journal International·Stephen J GalliMindy Tsai
Apr 20, 2021·The Journal of Allergy and Clinical Immunology·Daniel F Dwyer, Joshua A Boyce
Oct 5, 2021·European Journal of Immunology·Theres KlewerRolf Jessberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

© 2022 Meta ULC. All rights reserved