PMID: 9438912Jan 24, 1998Paper

The mast cell products histamine and serotonin stimulate and TNF-alpha inhibits the proliferation of murine epidermal keratinocytes in situ

Journal of Dermatological Science
M MaurerR Paus

Abstract

To better characterize the proposed growth modulatory functions of mast cells and their products in the regulation of epidermal homeostasis, we have assessed keratinocyte proliferation by incorporation of [3H]thymidine in murine skin organ cultures after incubation with different concentrations of histamine, serotonin or TNF-alpha. Both histamine and serotonin significantly stimulate the proliferation of keratinocytes as compared to controls (P < 0.001), reaching maxima within a range from micro- to nanomolar concentrations. Even at subnanomolar concentration, TNF-alpha significantly inhibits the incorporation of labelled thymidine by epidermal keratinocytes in murine skin organ culture (P < 0.001). These observations support the concept of mast cell products as modulators of keratinocyte proliferation, and suggest a role for mast cells in the regulation of epidermal tissue turnover under physiological conditions.

References

Jan 1, 1991·International Journal of Dermatology·M J Rothe, F A Kerdel
Jan 1, 1990·Archives of Dermatological Research·K NaganoY Niitsu
Jan 1, 1994·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·H BeeleL de Ridder
May 1, 1994·International Journal of Dermatology·A NaukkarinenM Horsmanheimo
May 1, 1994·Developmental Biology·R PausB M Czarnetzki
Jan 1, 1993·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·K S StennB Sarba
Aug 1, 1995·Experimental Dermatology·M MaurerB M Czarnetzki
May 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·D GLICK, S HOSODA

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Citations

Jun 24, 2006·Archives of Dermatological Research·Klas NordlindEfrain C Azmitia
Oct 8, 1999·Journal of Dermatological Science·H Koizumi, A Ohkawara
Jun 10, 2004·International Journal of Dermatology·Jianguo HuangRidong Chi
Nov 26, 2003·International Journal of Dermatology·A N Crowson, C M Magro
Jan 8, 2008·Experimental Dermatology·Klas NordlindAndrzej Slominski
Jan 23, 2009·The Journal of Investigative Dermatology·Zhongfa LuRalf Paus
Oct 31, 2002·The Journal of Investigative Dermatology·Andrzej SlominskiJacobo Wortsman
Apr 23, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Maria Andonova, Valentina Urumova
Oct 19, 2004·Biochimica Et Biophysica Acta·Andrzej SlominskiJacobo Wortsman
May 20, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Martin AnlaufEberhard Weihe
Mar 30, 2007·Regulatory Peptides·Øyvind HausoHelge L Waldum
May 27, 2003·Journal of Cellular Physiology·Andrzej SlominskiJacobo Wortsman
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SlominskiDesmond J Tobin
Sep 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karsten WellerMarcus Maurer
Jun 30, 2009·Expert Opinion on Pharmacotherapy·Hiroyuki Murota, Ichiro Katayama
Mar 3, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Miku AraiRyotaro Yoshida
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SlominskiOlle Johansson
Apr 22, 2009·Experimental Dermatology·Manfred Kneilling, Martin Röcken
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Jan 5, 2019·Clinical Science·Alessandro PiniArianna Carolina Rosa
Dec 26, 2018·Frontiers in Physiology·Hajime KarasuyamaSoichiro Yoshikawa
Oct 14, 2008·The Journal of Dermatological Treatment·Emine TamerNuran Alli
Oct 31, 2020·Parasite Immunology·Soichiro YoshikawaHajime Karasuyama
Jun 29, 2001·Mechanisms of Development·A HéronJ M Arrang
Nov 7, 2020·Frontiers in Immunology·Hajime KarasuyamaSoichiro Yoshikawa
May 15, 2021·The Biochemical Journal·Alejandro Cabezas-CruzJosé de la Fuente

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