The maternal brain under stress: Consequences for adaptive peripartum plasticity and its potential functional implications

Frontiers in Neuroendocrinology
David A Slattery, Katharina M Hillerer

Abstract

The peripartum period represents a time during which all mammalian species undergo substantial physiological and behavioural changes, which prepare the female for the demands of motherhood. In addition to behavioural and physiological alterations, numerous brain regions, such as the medial prefrontal cortex, olfactory bulb, medial amygdala and hippocampus are subject to substantial peripartum-associated neuronal, dendritic and synaptic plasticity. These changes, which are temporally- and spatially-distinct, are strongly influenced by gonadal and adrenal hormones, such as estrogen and cortisol/corticosterone, which undergo dramatic fluctuations across this period. In this review, we describe our current knowledge regarding these plasticity changes and describe how stress affects such normal adaptations. Finally, we discuss the mechanisms potentially underlying these neuronal, dendritic and synaptic changes and their functional relevance for the mother and her offspring.

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Citations

Mar 13, 2016·Frontiers in Neuroendocrinology·Benedetta Leuner, Sara Sabihi
Mar 19, 2016·Frontiers in Neuroendocrinology·Rand MahmoudLiisa A M Galea
Feb 6, 2018·Stress : the International Journal on the Biology of Stress·Katharina M HillererClaire-Dominique Walker
Feb 23, 2017·Psychopharmacology·D A Slattery, J F Cryan
Apr 26, 2017·Annual Review of Neuroscience·Noga ZilkhaTali Kimchi
Jul 17, 2018·Archives of Women's Mental Health·Erika Barba-MüllerElseline Hoekzema
Jan 12, 2021·Development and Psychopathology·Elysia Poggi Davis, Angela J Narayan
Oct 11, 2020·Frontiers in Neuroendocrinology·Pilyoung Kim
Jul 14, 2021·Human Nature : an Interdisciplinary Biosocial Perspective·Ivan NorsciaElisabetta Palagi

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