The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies

Journal of Immunology Research
Alicia Martínez-VareaAntonio Pellicer

Abstract

This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n = 25), in vitro fertilization (IVF; n = 25), and egg donation (ED; n = 25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1 beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies. Pregnant women in the three study groups displayed similar cytokine and chemokine pattern throughout pregnancy. The levels of all quantified cytokines and chemokines, except RANTES, TNFα, IL8, TGFβ, and SDF1α, rose in the second trimester compared with th...Continue Reading

References

Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aihua LiRakesh K Singh
Jan 4, 2006·Journal of Reproductive Immunology·Yvonne JonssonChristina Ekerfelt
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Rosanna RamhorstDanny Schust
Nov 15, 2006·Clinical Transplantation·U HoffmannB K Krämer
Dec 16, 2006·Reproductive Biomedicine Online·Marie-Pierre Piccinni
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Rosanna RamhorstLeonardo Fainboim
Apr 27, 2007·Clinical and Experimental Immunology·Y SasakiS Saito
Oct 16, 2007·Journal of Reproductive Immunology·Shigeru SaitoArihiro Shiozaki
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-KimAlice Gilman-Sachs
May 6, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Miğraci TosunErdal Malatyalioğlu
Jun 15, 2010·Human Reproduction Update·M L P van der HoornS A Scherjon
May 21, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Camilla S KronborgUlla B Knudsen
Nov 24, 2011·Clinical & Developmental Immunology·Shyi-Jou ChenHuey-Kang Sytwu
Sep 14, 2013·Journal of Reproductive Immunology·Marie-Louise P van der HoornSicco A Scherjon
Feb 5, 2014·The Journal of Endocrinology·Esteban GrassoRosanna Ramhorst
Jul 6, 2014·Journal of Immunology Research·Alicia Martínez-VareaAntonio Pellicer

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Citations

May 14, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Norma C SerranoJuan P Casas
Feb 7, 2020·International Journal of Molecular Sciences·Xuezi TianMarie-Louise van der Hoorn
Jul 28, 2019·Biology of Reproduction·Kelsey M HirschiJuan A Arroyo

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