The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia.

Current Biology : CB
Lisa J Funkhouser-JonesSeth R Bordenstein

Abstract

Maternal transmission of intracellular microbes is pivotal in establishing long-term, intimate symbioses. For germline microbes that exert negative reproductive effects on their hosts, selection can theoretically favor the spread of host genes that counteract the microbe's harmful effects. Here, we leverage a major difference in bacterial (Wolbachia pipientis) titers between closely related wasp species with forward genetic, transcriptomic, and cytological approaches to map two quantitative trait loci that suppress bacterial titers via a maternal effect. Fine mapping and knockdown experiments identify the gene Wolbachia density suppressor (Wds), which dominantly suppresses bacterial transmission from mother to embryo. Wds evolved by lineage-specific non-synonymous changes driven by positive selection. Collectively, our findings demonstrate that a genetically simple change arose by positive Darwinian selection in less than a million years to regulate maternally transmitted bacteria via a dominant, maternal effect gene.

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Citations

Sep 11, 2019·PLoS Pathogens·Jessamyn I PerlmutterSeth R Bordenstein
Jan 8, 2020·Nature Reviews. Microbiology·Jessamyn I Perlmutter, Seth R Bordenstein
Nov 22, 2019·FEMS Microbiology Letters·Sergio López-Madrigal, Elves H Duarte
Sep 26, 2020·ELife·J Dylan ShropshireSeth R Bordenstein
Mar 7, 2019·Nature Communications·Julie ReveillaudA Murat Eren
Oct 8, 2020·MBio·Michael T J HagueBrandon S Cooper
Nov 1, 2020·Biological Reviews of the Cambridge Philosophical Society·Ehsan SanaeiJan Engelstädter
Jan 30, 2021·Molecular Ecology·Benjamin J ParkerH Charles J Godfray
Apr 27, 2021·PLoS Pathogens·Holly L NicholsBenjamin J Parker
May 6, 2021·Biology Letters·Michael T J HagueBrandon S Cooper
May 5, 2021·Cell Host & Microbe·Rupinder KaurSeth R Bordenstein
Dec 26, 2021·Journal of Evolutionary Biology·Erik Sandertun Røed, Jan Engelstädter

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