The maternal-to-zygotic transition in bovine in vitro-fertilized embryos is associated with marked changes in small non-coding RNAs†

Biology of Reproduction
Jocelyn M CuthbertAbby D Benninghoff

Abstract

In mammals, small non-coding RNAs (sncRNAs) have been reported to be important during early embryo development. However, a comprehensive assessment of the inventory of sncRNAs during the maternal-to-zygotic transition (MZT) has not been performed in an animal model that better represents the sncRNA biogenesis pathway in human oocytes and embryos. The objective of this study was to examine dynamic changes in expression of sncRNAs during the MZT in bovine embryos produced by in vitro fertilization (IVF), which occurs at the 8-cell stage. An unbiased, discovery-based approach was employed using small RNAseq to profile sncRNAs in bovine oocytes, 8-cell stage embryos and blastocyst stage embryos followed by network and ontology analyses to explore the functional relevance of differentially expressed micro-RNAS (miRNAs). The relative abundance of miRNAs was markedly higher in 8-cell stage embryos compared to oocytes or blastocyst stage embryos. This shift in miRNA population was largely associated with upregulation of miRNAs predicted to target genes involved in the biological processes of cell development, cell division, Wnt signaling, and pluripotency, among others. Distinct populations of piwi-interacting-like RNAs (pilRNAs) were ...Continue Reading

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Citations

Apr 26, 2019·The Journal of Reproduction and Development·Kazuki TakahashiKen Sawai
Feb 14, 2020·Systems Biology in Reproductive Medicine·Stewart J RussellClifford Librach
Feb 23, 2020·International Journal of Molecular Sciences·Stefan BauersachsCarmen Almiñana
Jun 4, 2020·Cells·Minjie TanBernard A J Roelen
Mar 8, 2021·Journal of Animal Science·Lauren G ChukrallahElizabeth M Snyder
May 23, 2021·Reproduction in Domestic Animals = Zuchthygiene·Vanessa das Graças Pereira de SouzaLuiz Sérgio de Almeida Camargo
Jun 5, 2021·Biology of Reproduction·Jocelyn M CuthbertAbby D Benninghoff

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