The matriptase-prostasin proteolytic cascade in epithelial development and pathology.

Cell and Tissue Research
Gregory S Miller, Karin List

Abstract

The type II transmembrane serine protease matriptase has an essential role in the integrity and function of multiple epithelial tissues. In the epidermis, matriptase activates the glycosylphosphatidylinositol (GPI) anchored membrane serine protease prostasin to initiate a proteolytic cascade that is required for the development of the stratum corneum barrier function. Accordingly, mice deficient for matriptase phenocopy mice deficient for epidermal prostasin and present with impaired corneocyte differentiation, imparied lipid matrix formation, loss of profilaggrin processing and loss of tight junction formation and function. Together, these defects lead to a compromised epidermal barrier and result in fatal dehydration during the neonatal period. Proteolytic activity of the matriptase-prostasin cascade is regulated in the epidermis via inhibition by the Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-1 (HAI-1). Importantly, targeted post-natal ablation of matriptase in mice perturbs the function of multiple adult tissues, indicating an ongoing requirement for matriptase proteolysis in the maintenance of diverse types of epithelia. Impaired matriptase proteolytic activity has been linked to hum...Continue Reading

References

Jul 1, 1995·The British Journal of Dermatology·D L SmithR D deShazo
Jan 1, 1995·The Journal of Allergy and Clinical Immunology·D L SmithR D deShazo
Jan 1, 1993·Molecular and Cellular Biology·N G MarkovaP M Steinert
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·Grégoire VuagniauxEdith Hummler
Mar 29, 2001·The Journal of Biological Chemistry·L M ChenK X Chai
May 25, 2001·Journal of the American Society of Nephrology : JASN·Masataka AdachiKimio Tomita
Feb 14, 2002·The Journal of Investigative Dermatology·Emmanuelle BitounAlain Hovnanian
Apr 17, 2003·Current Topics in Developmental Biology·Qingyu Wu
May 10, 2003·The Journal of Biological Chemistry·Michael D OberstChen-Yong Lin
Jul 31, 2003·Thrombosis and Haemostasis·Roman SzaboThomas H Bugge
Nov 26, 2003·The Journal of Cell Biology·Karin ListThomas H Bugge
Jul 13, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zhenyue TongGeorge H Caughey
Oct 12, 2004·Biochemical and Biophysical Research Communications·Aaron ShipwayJennifer L Harris
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Michael D OberstChen-Yong Lin
Aug 3, 2005·The Journal of Cell Biology·Céline LeyvrazEdith Hummler
Sep 16, 2005·Genomics·Xose S PuenteCarlos López-Otín
Jan 31, 2006·Nature Genetics·Frances J D SmithW H Irwin McLean
Feb 8, 2006·Annual Review of Physiology·Christina M Van Itallie, James M Anderson
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mohammad SaleemHasan Mukhtar
Sep 19, 2006·The Journal of Biological Chemistry·Sarah Netzel-ArnettKarin List
Mar 9, 2007·American Journal of Physiology. Cell Physiology·Ming-Shyue LeeChen-Yong Lin

❮ Previous
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Citations

Jan 18, 2013·Cell and Tissue Research·Michael A Curtis, David P Kelsell
Apr 12, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Heiko FittlerHarald Kolmar
May 12, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Alexander MaiwaldTorsten Steinmetzer
Nov 15, 2016·Scientific Reports·Mingming ZhangJianxin Gu
Jan 18, 2017·The Journal of Clinical Investigation·Chuan-Jin WuMark C Udey
Aug 6, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalie J RonaghanWallace K MacNaughton
Apr 15, 2016·Biological Chemistry·Anna-Madeleine BeckmannMarit Stirnberg
Oct 30, 2018·Journal of Cellular and Molecular Medicine·Fang YeHu Zhou
Jul 18, 2020·The Journal of Biological Chemistry·Ce ZhangQingyu Wu
Feb 27, 2017·G3 : Genes - Genomes - Genetics·Anina BauerMonika M Welle
Nov 10, 2018·The Journal of Biological Chemistry·Trine TambergJan K Jensen
Dec 11, 2020·The FEBS Journal·Shuo LiQingyu Wu
Mar 25, 2021·Journal of the American Heart Association·Yayan NiuNingzheng Dong

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