The MatTek story - how the three Rs principles led to 3-D tissue success!

Alternatives to Laboratory Animals : ATLA
John SheasgreenDavid Ingalls

Abstract

MatTek Corporation has been working diligently for over 15 years to replace traditional animal-based toxicity and efficacy tests with alternative test methods based on human-cell derived, three-dimensional (3-D) tissue models. First discussed in detail by W.M.S. Russell and R.L. Burch 50 years ago in their book, The Principles of Humane Experimental Technique, and now fully integrated into forward-looking publications such as Toxicity Testing in the 21st Century: A Vision and a Strategy, the concept of replacing animals in test procedures with human cells and/or human cell-derived in vitro 3-D tissues is being embraced by the world's research scientists and toxicologists at an ever-increasing rate. 3-D in vitro models are being utilised not only for humanitarian reasons, but also because human 3-D tissues, in particular, produce more-physiologically relevant scientific data. Early on in MatTek's efforts to develop this alternative test method, senior management sought the assistance of experts within the in vitro testing and animal rights communities, to help define the specific in vitro human 3-D tissue products needed and navigate the regulatory landscape, especially in Europe where the replacement of animal-based testing wit...Continue Reading

References

Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemP A Botham
Sep 11, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C FallerR Roguet
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P PortesR Roguet
Sep 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Oleg V BelyakovDavid J Brenner
Apr 29, 2006·Regulatory Toxicology and Pharmacology : RTP·Amy RispinMitchell Klausner
Aug 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K KejlováM Liebsch
Aug 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M LiebschH Spielmann
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M SternM Dickens
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemM Liebsch
Aug 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C L CannonM Klausner

❮ Previous
Next ❯

Citations

Jan 1, 2013·Journal of Functional Biomaterials·Samantha L WilsonAndrew Hopkinson
Aug 15, 2017·Pharmacology Research & Perspectives·Rajkumar CheluvappaRajaraman Eri
Feb 6, 2021·In Vitro Cellular & Developmental Biology. Animal·Yulia Kaluzhny, Mitchell Klausner
Jun 22, 2021·Immunity, Inflammation and Disease·Victor Leyva-GradoNazlie Sadeghi-Latefi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.