PMID: 8955449Nov 1, 1996Paper

The maturation of human gene therapy

Acta Paediatrica
T Friedmann

Abstract

Human gene therapy is two things. It is the concept that human disease might be treated at the level of underlying genetic targets rather than at the level of aberrant metabolism, and it is the implementation of that concept toward a clinical reality. The conceptual aspect is established--gene therapy has become an accepted central driving force in medicine. The second aspect--that of converting the concepts into practical tools for human gene therapy--is maturing rapidly. Over the past several years, the level of expectation had risen to unrealistic proportions and recent initial clinical trials produced disappointment. These early clinical results should, however, be viewed not as failures, but rather as deliberate progress along the learning curve in this new and difficult field of biomedical science.

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Citations

Aug 24, 1999·The Journal of Urology·J J YooA Atala
Jun 6, 2000·Advanced Drug Delivery Reviews·R J LevyJ Bonadio
Dec 26, 2001·Neuroscience Letters·Chung Ren LinLin Cheng Yang
Mar 15, 2006·Dental Clinics of North America·Christoph A RamseierWilliam V Giannobile
Oct 14, 2006·Macromolecular Bioscience·Peter Dubruel, Etienne Schacht

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