Feb 9, 2008

The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics

Neuroepidemiology
Rosebud O RobertsWalter A Rocca

Abstract

The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia. The Olmsted County, Minn., population, aged 70-89 years on October 1, 2004, was enumerated using the Rochester Epidemiology Project. Eligible subjects were randomly selected and invited to participate. Participants underwent a comprehensive in-person evaluation including the Clinical Dementia Rating Scale, a neurological evaluation and neuropsychological testing. A consensus diagnosis of normal cognition, MCI or dementia was made by a panel using previously published criteria. A subsample of subjects was studied via telephone interview. Four hundred and two subjects with dementia were identified from a detailed review of their medical records but were not contacted. At baseline, we successfully evaluated 703 women aged 70-79 years, 769 women aged 80-89 years, 730 men aged 70-79 years and 517 men aged 80-89 years (total n = 2,719). Among the participants, 2,050 subjects were evaluated in person and 669 via telephone. Strengths of the study are that the subjects were randomly selected from a defined population, the majority of the subjects we...Continue Reading

  • References40
  • Citations229

References

  • References40
  • Citations229

Citations

Mentioned in this Paper

Senile Paranoid Dementia
Interview, Psychological
Memory for Designs Test
Severity of Illness Index
Incidence Studies
Senility
Bikinia le-testui
Clinical Dementia Rating Scale
Sex Distribution
Mild Cognitive Disorder

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