The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains

BMC Bioinformatics
Lisa C RomeroAnthony A James

Abstract

Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falciparum gene, MB2, were shown previously to have a stage-specific pattern of subcellular localization and proteolytic processing. Genes homologous to MB2 were identified in five additional parasite species, P. knowlesi, P. gallinaceum, P. berghei, P. yoelii, and P. chabaudi. Sequence comparisons among the MB2 gene products reveal amino acid conservation of structural features, including putative S1 and GTP-binding domains, and putative signal peptides and nuclear localization signals. The combination of domains is unique to this gene family and indicates that MB2 genes comprise a novel family and therefore may be a good target for drug development.

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Citations

Jan 7, 2011·Genome Research·Szymon M KiełbasaMartin C Frith
May 30, 2020·ELife·Slavica Pavlovic DjuranovicSergej Djuranovic
Feb 26, 2008·Journal of the American Chemical Society·Catarina F CorreiaGilles Ohanessian

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Methods Mentioned

BETA
transfection

Software Mentioned

PSIpred
SignalP
PSORT
Megalign
Clustal
BLAST
GENEDOC
SMART
TMpred
PROSITE

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