The Mcm complex: unwinding the mechanism of a replicative helicase.

Microbiology and Molecular Biology Reviews : MMBR
Matthew L Bochman, A Schwacha

Abstract

The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has illustrated that Mcm2-7 loading and activation are landmark events in the regulation of DNA replication. Unlike any other hexameric helicase, Mcm2-7 is composed of six unique and essential subunits. Although the unusual oligomeric nature of this complex has long hampered biochemical investigations, recent advances with both the eukaryotic as well as the simpler archaeal Mcm complexes provide mechanistic insight into their function. In contrast to better-studied homohexameric helicases, evidence suggests that the six Mcm2-7 complex ATPase active sites are functionally distinct and are likely specialized to accommodate the regulatory constraints of the eukaryotic process.

References

Jan 1, 1992·Annual Review of Biochemistry·E Fanning, R Knippers
Apr 1, 1992·Current Opinion in Genetics & Development·R Treisman, G Ammerer
Jan 23, 1992·Nature·R M StoryT A Steitz
Jun 1, 1991·Genes & Development·K M HennessyD Botstein
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M WrightJ Hurwitz
Jun 15, 1995·European Journal of Biochemistry·C MusahlR Knippers
Aug 1, 1995·Trends in Biochemical Sciences·A Sugino
Oct 1, 1994·Molecular Biology of the Cell·K TakahashiM Yanagida
Nov 9, 1994·Molecular and Cellular Biochemistry·T W Traut
Oct 1, 1993·Current Opinion in Genetics & Development·C S Newlon, J F Theis
May 31, 1996·Journal of Molecular Biology·X YuE H Egelman
Feb 1, 1996·Molecular Biology of the Cell·T T SuP H O'Farrell
Sep 27, 1996·The Journal of Biological Chemistry·Y IshimiH Kimura
Mar 1, 1996·Trends in Biochemical Sciences·J P ChongJ J Blow
Nov 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·H KimuraK Sugimoto
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·C F HardyR A Sclafani
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·M M HingoraniS S Patel
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·S DonovanJ F Diffley
Sep 26, 1997·The Journal of Biological Chemistry·Y Ishimi
Jul 1, 1997·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y AdachiM Yanagida
Jan 1, 1996·Progress in Cell Cycle Research·J P Chong, J J Blow
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M L AgarwalG R Stark
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·G ZhangJ Hurwitz

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Citations

Feb 24, 2012·Nature Reviews. Molecular Cell Biology·Constance Alabert, Anja Groth
Jul 16, 2013·Nature Structural & Molecular Biology·Jingchuan SunHuilin Li
Aug 5, 2011·The Journal of Biological Chemistry·Lin Ding, Susan L Forsburg
Apr 14, 2012·The Journal of Biological Chemistry·Avvaru N SuhasiniRobert M Brosh
Jan 4, 2013·The Journal of Biological Chemistry·Toshiaki NakanoHiroshi Ide
Aug 9, 2011·Nucleic Acids Research·Miao PanZvi Kelman
Nov 24, 2012·Nucleic Acids Research·Ramanagouda Ramanagoudr-BhojappaKevin D Raney
Mar 1, 2012·Nucleic Acids Research·Chen-Hua ChuangJohn C Schimenti
Jan 5, 2011·Genes & Development·Atsuya NishiyamaMarcel Méchali
Feb 13, 2013·Molecular and Cellular Biology·Jonghoon ParkAnindya Dutta
Feb 23, 2012·The Journal of Clinical Investigation·Jordan S Orange
May 9, 2012·BMC Genetics·Brent E SteadMegan J Davey
Jan 8, 2014·Chemical Society Reviews·S A Stratmann, A M van Oijen
Nov 30, 2013·Trends in Parasitology·Calvin TiengweRichard McCulloch
Mar 1, 2014·Medical Mycology·Branca M A SilvaArturo Casadevall
May 3, 2014·Archaea : an International Microbiological Journal·Felipe SarmientoWilliam B Whitman
Sep 23, 2014·BioMed Research International·Nicholas E Simon, Anthony Schwacha
Nov 1, 2011·FEBS Letters·Juan-juan LiStuart A MacNeill
May 11, 2016·Critical Reviews in Biochemistry and Molecular Biology·Nina Y Yao, Mike E O'Donnell
Feb 9, 2016·Nature Structural & Molecular Biology·Zuanning YuanHuilin Li
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Nima ParvanehMary Ellen Conley
Sep 22, 2015·Genesis : the Journal of Genetics and Development·Yunhai Luo, John C Schimenti
Aug 20, 2011·Current Opinion in Chemical Biology·Thomas R Beattie, Stephen D Bell
Sep 24, 2014·Neoplasia : an International Journal for Oncology Research·Mauricio QuimbayaGeert Berx
Aug 5, 2014·Molecular Cell·Sukhyun KangStephen P Bell

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