The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
David A SassDavid C Whitcomb

Abstract

Chronic pancreatitis (CP) is an inflammatory process initiated by recurrent acute pancreatitis and characterized by progressive parenchyma destruction and fibrosis. Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP. A genetic association study was performed on 177 CP patients and 116 healthy controls from the NAPS2 Study. The MCP-1 A/G genotype was determined by RFLP and confirmed by DNA sequencing. Compared to the control group the MCP-1 -2518 genotypes were similar: A/A (57% vs. 50%), A/G (34.5% vs. 40%) and G/G (8.5% vs. 10%). These allele frequencies were not statistically different (p = 0.267). Although the pro-inflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP.

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Citations

May 21, 2009·Annual Review of Genomics and Human Genetics·Jian-Min Chen, Claude Férec
Oct 18, 2007·Digestive Diseases and Sciences·Sang Hyub LeeYong Bum Yoon
Sep 4, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·David C WhitcombUNKNOWN North American Pancreatic Study Group
Oct 21, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·David C Whitcomb
Dec 17, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Fang FangJian Wang
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Monique H M Derikx, Joost P H Drenth

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