The mcr-9 Gene of Salmonella and Escherichia coli Is Not Associated with Colistin Resistance in the United States.

Antimicrobial Agents and Chemotherapy
Gregory H TysonShaohua Zhao

Abstract

Reports of transmissible colistin resistance show the importance of comprehensive colistin resistance surveillance. Recently, a new allele of the mobile colistin resistance (mcr) gene family designated mcr-9, which shows variation in genetic context and colistin susceptibility, was reported. We tested over 100 Salmonella enterica and Escherichia coli isolates with mcr-9 from the National Antimicrobial Resistance Monitoring System (NARMS) in the United States for their susceptibility to colistin and found that every isolate was susceptible, with an MIC of ≤1 μg/ml. Long-read sequencing of 12 isolates revealed mcr-9 on IncHI plasmids that were either independent or integrated into the chromosome. Overall, these results demonstrate that caution is necessary when determining the clinical relevance of new resistance genes.

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Citations

Aug 19, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Teresa Gonçalves RibeiroLuísa Peixe
Apr 3, 2021·International Journal of Antimicrobial Agents·Xiaoming WangLiping Wang
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Jul 6, 2021·JAC-antimicrobial Resistance·Antoni P A HendrickxUNKNOWN Dutch CPE surveillance Study Group
Jul 30, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ragheed KhodorSima Tokajian
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Aug 23, 2021·International Journal of Antimicrobial Agents·J Rodríguez-SantiagoU Garza-Ramos
Sep 4, 2021·Frontiers in Medicine·Firdoos Ahmad GogryQazi Mohd Rizwanul Haq
Oct 25, 2021·International Journal of Antimicrobial Agents·Jorge Arca-SuárezUNKNOWN GEMARA-SEIMC/REIPI Enterobacterales Study Group
Nov 22, 2021·International Journal of Antimicrobial Agents·Yasuhide KawamotoKatsunori Yanagihara

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