The MDM2 promoter T309G polymorphism was associated with preeclampsia susceptibility

Journal of Assisted Reproduction and Genetics
Saeedeh SalimiMinoo Yaghmaei

Abstract

Preeclampsia (PE) is a hypertensive disorder of pregnancy in which abnormal proliferation and apoptosis of placenta trophoblast has a pivotal role in its pathophysiology. The aim of the current study was to examine the association between Mouse Double Minute 2 (MDM2) T309G and 40 bp insertion/deletion (I/D) polymorphisms and PE risk. A case-control study was conducted on 208 PE women and 164 healthy pregnant women matching age, sex, and ethnicity. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR methods were used for genotyping. The MDM2 309GG genotype was associated with PE, and this genotype was found to be a risk factor for PE. There was no association between the MDM2 I/D polymorphism and PE. The haplotype-based association analysis revealed no association between MDM2 T309G and 40 bp I/D polymorphisms and PE. The frequency of TT-DD and GG-DD combined genotypes were significantly higher in PE women with marginal P values (P = 0.046). The MDM2 309GG genotype was associated with higher risk of PE. The TT-DD and GG-DD combined genotypes were higher in PE women.

References

Jul 1, 1993·Genes & Development·X WuA J Levine
May 15, 1997·Nature·Y HauptM Oren
Jan 1, 1997·Epidemiologic Reviews·J ZhangG Berkowitz
May 26, 1999·The Journal of Pathology·C Prives, P A Hall
Mar 22, 2001·The New England Journal of Medicine·M S EsplinM W Varner
Jul 29, 2004·DNA Repair·David W Meek
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naoki OhmiyaHidemi Goto
May 26, 2007·The American Journal of Pathology·Guy St J WhitleyJudith E Cartwright
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Andrew N SharpGil Mor
May 15, 2010·Journal of Hypertension·David M CartyAnna F Dominiczak
Jun 30, 2012·Pregnancy Hypertension·James M Roberts, C Escudero
Dec 19, 2012·Human Genomics·Marie-Eve LalondeDaniel Sinnett
Apr 3, 2014·The Journal of Obstetrics and Gynaecology Research·Saeedeh SalimiMinoo Yaghmaei
Dec 17, 2014·The Journal of Obstetrics and Gynaecology Research·Saeedeh SalimiMinoo Yaghmaei
Jul 1, 2011·Pregnancy Hypertension·D BerksW Visser
Sep 9, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhuowei XueYincheng Teng
Jan 24, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivanir Celso OrlandoCristina Wide Pissetti

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Citations

Jan 31, 2018·Journal of Cellular Biochemistry·Mahdiyeh Harati-SadeghSaeedeh Salimi
Oct 7, 2019·Medicinal Research Reviews·Wei WangRuiwen Zhang
Jan 9, 2019·Frontiers in Physiology·Rafael Tomoya MichitaJosé Artur Bogo Chies

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