Feb 1, 1976

The meaning of the Leydig cell in relation to the etiology of cryptorchidism: An experimental electron-microscopic study

Journal of Pediatric Surgery
F Hadziselimović, B Herzog


In our electron-microscopic studies of testicular biopsies, both normal and cryptorchid, we found a simple atrophy of the Leydig cell in the cryptorchid testis. Based on experiments by Raynaud1,2 and Jean3 on pregnant mice, we tried to find the reason for changes in the Leydig cell relating to the etiology of cryptorchidism. We found on electron microscopic study of testes in the offspring of pregnant mice treated with estrogen the same atrophy of the Leydig cell as we see in human cryptorchidism. These changes are not evident when estrogen and HCG are given together. We can conclude from this experiment that lack of gonadotropin stimulation leads to the atrophy of Leydig cells. This atrophy then produces a lack of androgen which could be responsible for cryptorchidism.

  • References2
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Mentioned in this Paper

Benign Neoplasm of Testis
Androgen Effect
Neoplasm of Uncertain or Unknown Behavior of Testis
Gonadotropin [EPC]
Structure of Interstitial Cell of Leydig
Inferior Colliculus

About this Paper

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