PMID: 1483Feb 1, 1976

The meaning of the Leydig cell in relation to the etiology of cryptorchidism: An experimental electron-microscopic study

Journal of Pediatric Surgery
F Hadziselimovic, B Herzog


In our electron-microscopic studies of testicular biopsies, both normal and cryptorchid, we found a simple atrophy of the Leydig cell in the cryptorchid testis. Based on experiments by Raynaud1,2 and Jean3 on pregnant mice, we tried to find the reason for changes in the Leydig cell relating to the etiology of cryptorchidism. We found on electron microscopic study of testes in the offspring of pregnant mice treated with estrogen the same atrophy of the Leydig cell as we see in human cryptorchidism. These changes are not evident when estrogen and HCG are given together. We can conclude from this experiment that lack of gonadotropin stimulation leads to the atrophy of Leydig cells. This atrophy then produces a lack of androgen which could be responsible for cryptorchidism.


Dec 1, 1982·European Journal of Pediatrics·F Hadziselimovic
Jan 1, 1987·European Journal of Pediatrics·J C JobP Canlorbe
Mar 19, 2004·Current Urology Reports·J C Trussell, Peter A Lee
Jun 21, 2002·European Urology·F Hadziselimovic
Feb 1, 1991·International Journal of Andrology·L Murphy, P J O'Shaughnessy
Oct 25, 2013·Molecular and Cellular Endocrinology·Cristina CoccoBarbara Noli
Aug 1, 1982·International Journal of Andrology·V BaumansC J Wensing
Dec 1, 1983·International Journal of Andrology·V BaumansC J Wensing
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·M GuarinoE Cristofori
Sep 23, 2003·Sociology of Health & Illness·Karen Lowton, Jonathan Gabe
Apr 1, 1984·The Journal of Urology·X Cortada, B G Kousseff
Jan 1, 1978·Archives of Andrology·B ColenbranderC J Wensing
Jan 1, 1982·The Journal of Urology·B FallonC Hawtrey

Related Concepts

Androgen Effect
Unilateral Cryptorchidism
Estrogen Effect
Structure of Interstitial Cell of Leydig
Maternal-Fetal Exchange

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