PMID: 7336924Dec 1, 1981Paper

The measles virus-specific protein synthesis of persistently and lytically infected cells studied in vivo and in vitro

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
R VainionpääT Hyypiä

Abstract

The virus-specific protein synthesis of the hamster brain cells persistently infected with a wild-type measles virus (M-MB/MVB) was investigated in vivo and in vitro and compared to the protein synthesis of the Vero-cells lytically infected with the wild-type measles virus and the SSPE-measles virus strain LEC. The virus-specific protein synthesis in the M-HB/MVB-cells in vivo was weak. Only two virus-specific polypeptides, corresponding to polypeptide G and nucleocapsid polypeptide NP, were detected. On the other hand, the in vitro translation products, coded by the RNA extracted from the actinomycin D-treated M-HB/MVB-cells, were similar compared to those products coded by the RNAs from the lytically infected Vero-cells. The polypeptides with MWs of 75 000, 61 000, 40 000, 37 000 and 18 000 were coded with all three RNA-extracts. So the similar mRNAs were induced in the actinomycin D-treated M-HB/MVB-cells, but their translation in vivo was limited. In addition to those polypeptides mentioned above the polypeptide with a MW of 42 000 was detected among the in vitro translation products of the M-HB/MVB-cells.

References

Jul 15, 1979·Virology·A Niveleau, T F Wild
Jan 1, 1979·Archives of Virology·R Vainionpää
Jul 1, 1977·Journal of Virology·R W PelusoP W Choppin
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W W HallP W Choppin
Nov 1, 1979·Journal of Virology·J SpragueJ B Milstien
Feb 1, 1978·Journal of Virology·J M Hardwick, R H Bussell
May 1, 1978·The Journal of General Virology·D L Tyrrell, E Norrby
May 1, 1978·Virology·M C GravesP W Choppin
Jan 1, 1978·Intervirology
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Jan 1, 1977·Journal of Virology·A M BreschkinF E Payne
May 15, 1977·Virology·W E Mountcastle, P W Choppin
Jul 1, 1975·The Journal of General Virology·E A Gould, P E Linton
Oct 1, 1975·The Journal of Experimental Medicine·B S Joseph, M B Oldstone
Jan 1, 1974·Medical Microbiology and Immunology·W W HallE Gould
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·G Barbanti-BrodanoH Koprowski
May 15, 1974·Journal of Molecular Biology·J L SaborioG Koch
Jun 4, 1974·Biochemistry·V GlisinC Byus
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.