PMID: 6978457Jan 1, 1982Paper

The measurement of leukocyte subsets in the peripheral blood of cancer patients with solid tumors using monoclonal antibody reagents

Medical and Pediatric Oncology
J E HarrisD P Braun

Abstract

Monocyte and lymphocyte subsets were quantitated in the peripheral blood of normal subjects and patients with solid tumors using the monoclonal antibody reagents OKM1, BRL63D3, OKT3, OKT4, and OKT8. Percentages and numbers of cells reacting with monoclonal reagents were analyzed by indirect immunofluorescence. Correlations between leukocyte subset values and stage of disease or immunocompetence were sought. No differences from normal were seen in the percentage of OKT3, OKT4, and OKT8 cells or in the ratios of OKT4/OKT8 cells in peripheral blood mononuclear cells (PBMC) from all cancer patients, patients with localized disease, or patients with advanced disease. A significant decrease in absolute numbers of lymphocytes, OKT3 cells, OKT4 cells, and OKT8 cells was seen in the peripheral blood of patients with advanced disease reflecting the absolute lymphopenia of these patients. A significant increase was seen in the percentages of PBMC reacting with OKM1 and BRL63D3 from patients with advanced disease compared with normal donors or localized disease patients. A positive correlation was found between PHA responsiveness and absolute numbers of OKT3 and OKT4 cells. A negative correlation was found between PHA responsiveness and pe...Continue Reading

References

Oct 1, 1977·American Journal of Surgery·E Y HilalH F Oettgen
Sep 1, 1979·Journal of the National Cancer Institute·G W WoodR Stephens
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·V UgoliniJ D Capra

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