PMID: 2576011Dec 1, 1989

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types

Genes & Development
J C Way, M Chalfie

Abstract

The homeo-box-containing gene mec-3 of the nematode Caenorhabditis elegans, is expressed in several sensory neurons, as assayed by expression of a mec-3-lacZ fusion. These cells are the touch receptors, which mediate the response to gentle touch, and the FLP and PVD neurons. PVD mediates a response to harsh mechanical stimuli, and FLP has an ultrastructure suggestive of a mechanoreceptor, but its function is unknown. mec-3 is necessary for the differentiation of the touch receptors, because in mec-3 mutants, the touch receptors do not function and have none of their distinguishing features. mec-3 is also needed for PVD function: The PVD neurons no longer mediate a response to harsh mechanical stimuli in the mutants. The expression of the mec-3-lacZ fusion, and presumably mec-3 itself, is altered by mutations in several genes originally identified by their effects on touch cell development. unc-86, another homeo-box-containing gene, is necessary for all mec-3-lacZ expression, but also affects several other lineages and cells in which mec-3 is not expressed. mec-3 activity appears to be required for maintained expression of the mec-3-lacZ fusion in all cells in which it is expressed. In a mec-17 mutant, mec-3-lacZ expression is n...Continue Reading

References

Jan 1, 1996·Developmental Genetics·P Sengupta, C I Bargmann
Mar 21, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Curtiss, J S Heilig
Aug 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J C WayA Y Wang
Dec 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C WayM S Hung
Mar 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Herman
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, M Chalfie
Jun 1, 1996·Trends in Neurosciences·A N AkopianJ N Wood
Apr 29, 1993·Biochimica Et Biophysica Acta·C P Verrijzer, P C Van der Vliet
Feb 1, 1992·Current Opinion in Neurobiology·W G Wadsworth, E M Hedgecock
Dec 29, 1998·Trends in Genetics : TIG·M Chalfie, E M Jorgensen
Feb 1, 2000·Trends in Genetics : TIG·O Hobert, H Westphal
Aug 1, 1996·Current Opinion in Neurobiology·J M Kaplan
Nov 13, 1998·Current Opinion in Neurobiology·C A CallahanJ B Thomas
Jun 1, 2010·Nature Neuroscience·Marios ChatzigeorgiouWilliam R Schafer
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Oliver Hobert
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini TopalidouM Chalfie
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alexander BounoutasM Chalfie
Nov 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini Topalidou, M Chalfie
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S L MansourM R Capecchi
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M Kaplan, H R Horvitz
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·G GuM Chalfie
Mar 1, 1991·The Journal of Cell Biology·H M Blau, D Baltimore
Nov 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pengxiu CaoZhaoyang Feng
Jul 4, 2007·Genes & Development·John F EtchbergerOliver Hobert
Mar 29, 2001·Genes & Development·J WuM Chalfie
Feb 3, 1999·Annals of the New York Academy of Sciences·J R Fetcho, K S Liu
May 8, 2010·Science·Meital Oren-SuissaBenjamin Podbilewicz
Jan 1, 1997·Annual Review of Neuroscience·J Garcia-Anoveros, D P Corey
Jan 1, 1997·Annual Review of Physiology·N Tavernarakis, Monica Driscoll
Jan 14, 2003·Annual Review of Physiology·Miriam B Goodman, Erich M Schwarz
Oct 1, 2010·Journal of Neurophysiology·Marios ChatzigeorgiouWilliam R Schafer
Dec 18, 2013·BMC Neuroscience·Jarred SandersDavid Biron
Jul 5, 2013·BMC Neuroscience·Aylia MohammadiWilliam S Ryu

Related Concepts

Transformation, Genetic
Caenorhabditis elegans
Neurons
Lac Gene
ATAT1 wt Allele
Gene Expression
Cell Differentiation Process
Terminal Differentiation
Cell Development
Neuronal

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