The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals

doi:10.1038/nn1362

PMID: 15580270DOI: 10.1038/nn1362Dec 8, 2004

The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals

Nature Neuroscience

Robert O'HaganM B Goodman

Abstract

Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external force evokes rapidly activating mechanoreceptor currents (MRCs) carried mostly by Na(+) and blocked by amiloride-characteristics consistent with direct mechanical gating of a DEG/ENaC channel. Like mammalian Pacinian corpuscles, these neurons depolarized with both positive and negative changes in external force but not with sustained force. Null mutations in the DEG/ENaC gene mec-4 and in the accessory ion channel subunit genes mec-2 and mec-6 eliminated MRCs. In contrast, the genetic elimination of touch neuron-specific microtubules reduced, but did not abolish, MRCs. Our findings link the application of external force to the activation of a molecularly defined metazoan sensory transduction channel.

References

Response latency of vertebrate hair cells

Jun 1, 1979·Biophysical Journal·David P Corey, A J Hudspeth

Nonstationary noise analysis and application to patch clamp recordings

Jan 1, 1992·Methods in Enzymology·S H Heinemann, F Conti

Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons

Feb 24, 1989·Science·Martin Chalfie, M Au

mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans

Jun 1, 1989·Genes & Development·C SavageMartin Chalfie

Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans

Apr 1, 1982·The Journal of Cell Biology·Martin Chalfie, J N Thomson

Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans

Mar 1, 1981·Developmental Biology·Martin Chalfie, J Sulston

A stomatin-like protein necessary for mechanosensation in C. elegans

Nov 16, 1995·Nature·M HuangMartin Chalfie

Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans

Feb 3, 1994·Nature·M Huang, Martin Chalfie

Sodium-dependent receptor current in a new mechanoreceptor preparation

Dec 1, 1994·Journal of Neurophysiology·M JuusolaA S French

Reverse genetics: from gene sequence to mutant worm

Jan 1, 1995·Methods in Cell Biology·R H Plasterk

unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion

Jan 1, 1997·Neuron·Nektarios TavernarakisMonica Driscoll

Ionic selectivity of mechanically activated channels in spider mechanoreceptor neurons

Oct 27, 1997·Journal of Neurophysiology·U HögerA S French

Active currents regulate sensitivity and dynamic range in C. elegans neurons

May 15, 1998·Neuron·M B GoodmanShawn R Lockery

A Drosophila mechanosensory transduction channel

Apr 1, 2000·Science·R G WalkerC S Zuker

Pressure polishing: a method for re-shaping patch pipettes during fire polishing

Oct 21, 2000·Journal of Neuroscience Methods·M B Goodman, Shawn R Lockery

The mammalian sodium channel BNC1 is required for normal touch sensation

Nov 9, 2000·Nature·M P PriceMichael J Welsh

Localization of beta and gamma subunits of ENaC in sensory nerve endings in the rat foot pad

Nov 18, 2000·Brain Research·Heather A DrummondMichael J Welsh

The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice

Jan 5, 2002·Neuron·M P PriceMichael J Welsh

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation

Mar 5, 2002·Nature·M B GoodmanMartin Chalfie

Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure

Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild

Identification of genes expressed in C. elegans touch receptor neurons

Jul 19, 2002·Nature·Yun ZhangMartin Chalfie

Genetics of sensory mechanotransduction

Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel

Dec 13, 2002·Nature·Dattananda S ChelurMartin Chalfie

Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1

Sep 6, 2003·Current Biology : CB·Joshua A AinsleyWayne A Johnson

In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation

Sep 16, 2003·Neuron·Hiroshi SuzukiWilliam R Schafer

Local responses in Pacinian corpuscles

Jan 1, 1953·The American Journal of Physiology·R ALVAREZ-BUYLLA, J RAMIREZ DE ARELLANO

Properties of the receptor potential in Pacinian corpuscles

Dec 29, 1953·The Journal of Physiology·J A GRAY, M SATO

The relation between receptor potentials and the concentration of sodium ions

Jul 14, 1958·The Journal of Physiology·J DIAMONDD R INMAN

THE EFFECT OF SODIUM DEFICIENCY ON THE RESPONSE OF THE ISOLATED MUSCLE SPINDLE

May 1, 1964·The Journal of Physiology·D OTTOSON

Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing

Jun 1, 2004·The Journal of Physiology·Carolina RozaRainer Waldmann

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain

Nov 9, 2004·Current Biology : CB·Shifang ZhangMartin Chalfie

Citations

Nociceptors: a phylogenetic view

Oct 16, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ewan St John Smith, Gary R Lewin

Twenty odd years of stretch-sensitive channels

Oct 6, 2006·Pflügers Archiv : European journal of physiology·O P Hamill

The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans

Sep 23, 2008·Development Genes and Evolution·Patricia GordonKathleen M Raley-Susman

Strongly alkaline pH avoidance mediated by ASH sensory neurons in C. elegans

Jun 19, 2013·Neuroscience Letters·Toshihiro SassaIchi N Maruyama

The schistosome in the mammalian host: understanding the mechanisms of adaptation

Jun 19, 2007·Parasitology·J R KuselM J Doenhoff

Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity

Aug 2, 2008·Cell Death and Differentiation·W ZhangMonica Driscoll

Insights into social insects from the genome of the honeybee Apis mellifera

Oct 31, 2006·Nature·Honeybee Genome Sequencing Consortium

A stomatin-domain protein essential for touch sensation in the mouse

Dec 15, 2006·Nature·Christiane WetzelGary R Lewin

The role of Drosophila Piezo in mechanical nociception

Feb 22, 2012·Nature·Sung Eun KimArdem Patapoutian

The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans

May 19, 2011·Nature Communications·Wei LiX Z Shawn Xu

Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans

Jun 16, 2011·Nature Communications·Atsushi KuharaIkue Mori

Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction

Nov 3, 2011·Nature Communications·Anthony W PengAnthony J Ricci

Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans

Apr 7, 2010·Nature Methods·Andrea CalixtoMartin Chalfie

Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans

Jul 29, 2008·Nature Neuroscience·Daniel RamotM B Goodman

Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons

Apr 7, 2010·Nature Neuroscience·Sreekanth H ChalasaniCornelia I Bargmann

Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors

Jun 1, 2010·Nature Neuroscience·Marios ChatzigeorgiouWilliam R Schafer

Metazoan mechanotransduction mystery finally solved

Dec 29, 2004·Nature Neuroscience·Diane Ronan, Peter Gillespie

Caenorhabditis elegans TRPA-1 functions in mechanosensation

Apr 24, 2007·Nature Neuroscience·Katie S KindtWilliam R Schafer

Profile of Martin Chalfie

Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tinsley Davis

GFP: Lighting up life

Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin Chalfie

Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway

Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alexander BounoutasMartin Chalfie

Stiffened lipid platforms at molecular force foci

Mar 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andriy Anishkin, Ching Kung

Three homologous subunits form a high affinity peptide-gated ion channel in Hydra

Feb 18, 2010·The Journal of Biological Chemistry·Stefan DürrnagelStefan Gründer

A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)

Jul 27, 2010·The Journal of Biological Chemistry·Dominik Wiemuth, Stefan Gründer

STR-33, a novel G protein-coupled receptor that regulates locomotion and egg laying in Caenorhabditis elegans

Sep 23, 2011·The Journal of Biological Chemistry·Jeong-Eui LeeYoung-Ki Paik

Pickpocket1 is an ionotropic molecular sensory transducer

Oct 4, 2012·The Journal of Biological Chemistry·Nina BoikoBenjamin A Eaton

Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels

Dec 17, 2008·The Journal of Biological Chemistry·Tianbo LiCecilia M Canessa

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

Jan 31, 2007·The Journal of General Physiology·Austin L BrownM B Goodman

MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity

May 28, 2008·The Journal of General Physiology·Austin L BrownM B Goodman

Perspectives on: information and coding in mammalian sensory physiology: probing mammalian touch transduction

Aug 31, 2011·The Journal of General Physiology·Diana M Bautista, Ellen A Lumpkin

High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra

Sep 26, 2012·The Journal of General Physiology·Stefan DürrnagelStefan Gründer

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons

Jul 10, 2012·Open Biology·Liudmila LapatsinaPaul A Heppenstall

Sexy DEG/ENaC channels involved in gustatory detection of fruit fly pheromones

Nov 8, 2012·Science Signaling·Claudio W Pikielny

Transient receptor potential channels and mechanosensation

Jun 12, 2013·Annual Review of Neuroscience·Niels EijkelkampJohn N Wood

Eukaryotic mechanosensitive channels

Mar 3, 2010·Annual Review of Biophysics·Jóhanna Arnadóttir, Martin Chalfie

The Walter B. Cannon Memorial Award Lecture, 2009. Physiology in perspective: The wisdom of the body. In search of autonomic balance: the good, the bad, and the ugly

Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·François M Abboud

ENaC structure and function in the wake of a resolved structure of a family member

Jul 15, 2011·American Journal of Physiology. Renal Physiology·Ossama B Kashlan, Thomas R Kleyman

Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10

Oct 1, 2010·Journal of Neurophysiology·Marios ChatzigeorgiouWilliam R Schafer

Worm sensation!

Apr 9, 2005·Molecular Pain·Liam J Drew, John N Wood

ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster

Mar 23, 2012·PLoS Genetics·Beika LuYehuda Ben-Shahar

Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss

Jan 10, 2013·PLoS Genetics·Andrea CalixtoFelipe A Court

The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function

Mar 3, 2010·PloS One·Yehuda Ben-ShaharMichael J Welsh

Molecular modeling of mechanosensory ion channel structural and functional features

Sep 30, 2010·PloS One·Renate GessmannNektarios Tavernarakis

Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity

Apr 17, 2012·PloS One·Sinyoung KangTimothy J Brennan

Functional phenotypic rescue of Caenorhabditis elegans neuroligin-deficient mutants by the human and rat NLGN1 genes

Jun 23, 2012·PloS One·F Calahorro, Manuel Ruiz-Rubio

The star-nosed mole reveals clues to the molecular basis of mammalian touch

Feb 6, 2013·PloS One·Kristin A GerholdDiana M Bautista

Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa

Jun 21, 2013·PloS One·David L Prole, Colin W Taylor

touché Is required for touch-evoked generator potentials within vertebrate sensory neurons

Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean E LowLouis Saint-Amant

Two novel DEG/ENaC channel subunits expressed in glia are needed for nose-touch sensitivity in Caenorhabditis elegans

Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lu HanLaura Bianchi

The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons

Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jóhanna ArnadóttirMartin Chalfie

Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans

Aug 28, 2007·Genetics·Nahui KimJi Y Sze

Mechanosensation

Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·M B Goodman

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

Mar 26, 2014·Nature Communications·Kate PooleGary R Lewin

Targeted cell killing by reconstituted caspases

Feb 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dattananda S Chelur, Martin Chalfie

Analysis of nematode mechanics by piezoresistive displacement clamp

Oct 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sung-Jin ParkB L Pruitt

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tobias B HuberThomas Benzing

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sanjeev S RanadeArdem Patapoutian

Molecular evolution of the vertebrate mechanosensory cell and ear

Sep 25, 2007·The International Journal of Developmental Biology·Bernd FritzschGarrett Soukup

The quest for action potentials in C. elegans neurons hits a plateau

Mar 27, 2009·Nature Neuroscience·Shawn R Lockery, M B Goodman

Insight into DEG/ENaC channel gating from genetics and structure

Oct 3, 2012·Physiology·Amy L Eastwood, M B Goodman

Phylogenetic conservation of the cell-type-specific Lan3-2 glycoepitope in Caenorhabditis elegans

Jun 22, 2010·Development Genes and Evolution·Harper C VansteenhouseBirgit Zipser

The ionic dependence of voltage-activated inward currents in the pharyngeal muscle of Caenorhabditis elegans

Apr 20, 2006·Invertebrate Neuroscience : in·Irina VinogradovaLindy Holden-Dye

Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans

Oct 24, 2007·Molecular Neurobiology·Laura Bianchi

Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders

Mar 16, 2013·Molecular Neurobiology·Carlos BessaAna João Rodrigues

From actomyosin oscillations to tissue-level deformations

Oct 29, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicole Gorfinkiel

The cell biology of touch

Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson

Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae

Dec 3, 2014·Current Biology : CB·Stephanie E MauthnerW Daniel Tracey

Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles

Nov 18, 2009·The Journal of Physiology·Anna SimonGuy S Bewick

Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1

Nov 20, 2013·The Journal of Physiology·Alexey KozlenkovEwan St John Smith

Architectural and functional similarities between trimeric ATP-gated P2X receptors and acid-sensing ion channels

Jun 18, 2014·Journal of Molecular Biology·Stephan Kellenberger, Thomas Grutter

Sodium channels and mammalian sensory mechanotransduction

Mar 28, 2012·Molecular Pain·Ramin RaoufJohn N Wood

Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity

Aug 21, 2013·The Journal of Physiology·Rabih MoshourabGary R Lewin

Tissue mechanics govern the rapidly adapting and symmetrical response to touch

Dec 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Amy L EastwoodM B Goodman

Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans

Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yushu ChenMartin Chalfie

Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons

Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hao-Ching JiangChun-Liang Pan

Sensing pressure with ion channels

May 25, 2012·Trends in Neurosciences·Bernd Nilius, Eric Honoré

Intensity discrimination deficits cause habituation changes in middle-aged Caenorhabditis elegans

May 12, 2012·Neurobiology of Aging·Tiffany A TimbersCatharine H Rankin

How does morphology relate to function in sensory arbors?

Aug 16, 2011·Trends in Neurosciences·David H Hall, Millet Treinin

Stomatin-domain proteins

Apr 20, 2011·European Journal of Cell Biology·Liudmilla LapatsinaGary R Lewin

Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions

Sep 21, 2010·Current Opinion in Cell Biology·Takeshi Kobayashi, Masahiro Sokabe

Molecular basis of mechanosensitivity

Aug 18, 2009·Autonomic Neuroscience : Basic & Clinical·Stuart M Brierley

Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel (ENaC) in the skin

Nov 6, 2014·The Journal of Investigative Dermatology·Wei XuThomas A Mustoe

Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction

Mar 18, 2008·Progress in Biophysics and Molecular Biology·Joost H A FolgeringEric Honoré

TRPC6 in glomerular health and disease: what we know and what we believe

Nov 23, 2006·Seminars in Cell & Developmental Biology·Johannes S Schlöndorff, Martin R Pollak

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development

Mar 27, 2009·The EMBO Journal·Stefan G LechnerGary R Lewin

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Nov 18, 2008·Microscopy Research and Technique·J A VegaJuan M Cobo

Nobel Prizes 2008

Dec 30, 2008·Angewandte Chemie

Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins

Mar 31, 2012·Microscopy Research and Technique·M E Del ValleJ A Vega

Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behaviour

Mar 6, 2013·Biology of the Cell·Steven J HussonAndrew M Leifer

Neurosensory mechanotransduction through acid-sensing ion channels

Mar 16, 2013·Journal of Cellular and Molecular Medicine·Chih-Cheng Chen, Chia-Wen Wong

A stomatin dimer modulates the activity of acid-sensing ion channels

Aug 2, 2012·The EMBO Journal·Janko BrandOliver Daumke

NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells

Nov 12, 2010·Cytoskeleton·Xin LiangJonathon Howard

Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants

May 4, 2013·Genes, Brain, and Behavior·F Calahorro, Manuel Ruiz-Rubio

NOMPC is likely a key component of Drosophila mechanotransduction channels

Apr 18, 2013·The European Journal of Neuroscience·Jiaxin GongZuoren Wang

The effects of hemodynamic force on embryonic development

Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·James C Culver, Mary E Dickinson

Evidence for a protein tether involved in somatic touch

Jan 16, 2010·The EMBO Journal·Jing HuGary R Lewin

Mechanical systems biology of C. elegans touch sensation

Jan 20, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael KriegM B Goodman

FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides

Mar 7, 2006·Peptides·Eric LinguegliaMichel Lazdunski

Feeling the pressure in mammalian somatosensation

Jul 19, 2005·Current Opinion in Neurobiology·Ellen A Lumpkin, Diana M Bautista

Feeling force: physical and physiological principles enabling sensory mechanotransduction

Nov 14, 2015·Annual Review of Cell and Developmental Biology·Samata KattaM B Goodman

Sensory systems: their impact on C. elegans survival

Jul 6, 2014·Neuroscience·E N AllenJ Alcedo

The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation

Jan 13, 2010·Neuron·Yongjun LuFrançois M Abboud

Mechanically Activated Ion Channels

Sep 25, 2015·Neuron·Sanjeev S RanadeArdem Patapoutian

Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1

Aug 16, 2014·Neuron·Masha Prager-KhoutorskyCharles W Bourque

ASICs and mammalian mechanoreceptor function

Dec 22, 2014·Neuropharmacology·Damir OmerbašićGary R Lewin

Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans

Jun 12, 2010·Developmental Biology·Cody J SmithDavid M Miller

The neuroethology of C. elegans escape

Jan 10, 2012·Current Opinion in Neurobiology·Jennifer K Pirri, Mark J Alkema

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins

Mar 5, 2016·Molecular Biology of the Cell·Yushu ChenMartin Chalfie

The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission

Oct 15, 2014·BMC Biology·Marc AssmannStefan Gründer

Hypotonic stimuli enhance proton-gated currents of acid-sensing ion channel-1b

Dec 27, 2007·Biochemical and Biophysical Research Communications·Shinya UgawaShoichi Shimada

ASICs and cardiovascular homeostasis

Jan 17, 2015·Neuropharmacology·François M Abboud, Christopher J Benson

Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch

Dec 30, 2014·Peptides·Jason C CampbellWilliam G Bendena

Worms under Pressure: Bulk Mechanical Properties of C. elegans Are Independent of the Cuticle

Apr 23, 2015·Biophysical Journal·William GilpinClifford P Brangwynne

Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases

Mar 28, 2009·Neuron·Manuel ZimmerCornelia I Bargmann

C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel

Aug 11, 2010·Neuron·Lijun KangX Z Shawn Xu

Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans

Apr 28, 2011·Neuron·Marios Chatzigeorgiou, William R Schafer

How we feel: ion channel partnerships that detect mechanical inputs and give rise to touch and pain perception

May 29, 2012·Neuron·Shana L Geffeney, M B Goodman

Stimulus discrimination by the polymodal sensory neuron

Jun 12, 2013·Communicative & Integrative Biology·James D Stockand, Benjamin A Eaton

Proprioception: a channel for body sense in the worm

Jul 11, 2006·Current Biology : CB·William R Schafer

Deciphering the neural and molecular mechanisms of C. elegans behavior

Sep 6, 2005·Current Biology : CB·William R Schafer

Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules

Jun 5, 2012·Current Biology : CB·Juan G CuevaM B Goodman

Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae

Feb 23, 2010·Current Biology : CB·Lixian ZhongW Daniel Tracey

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear

Jul 23, 2013·Neuron·Bifeng PanJeffrey R Holt

Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses

Dec 20, 2005·Current Biology : CB·Georg NagelAlexander Gottschalk

The C. elegans touch response facilitates escape from predacious fungi

Aug 2, 2011·Current Biology : CB·Sean M MaguireMark J Alkema

Mechanosensitive channels: in touch with Piezo

Nov 9, 2010·Current Biology : CB·Rui Xiao, X Z Shawn Xu

Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors

Apr 10, 2012·Current Biology : CB·Steven J HussonAlexander Gottschalk

DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor

Sep 10, 2011·Neuron·Shana L GeffeneyM B Goodman

Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae

Oct 30, 2012·Current Biology : CB·Asako TsubouchiW Daniel Tracey

Mechanosensitive channels: what can they do and how do they do it?

Oct 18, 2011·Structure·Elizabeth S HaswellDouglas C Rees

Dopamine mediates context-dependent modulation of sensory plasticity in C. elegans

Aug 19, 2007·Neuron·Katie S KindtWilliam R Schafer

The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation

Jul 21, 2009·Current Biology : CB·Alexander BounoutasMartin Chalfie

Mechanisms of mechanotransduction

Jan 10, 2006·Developmental Cell·A Wayne OrrMartin A Schwartz

Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation

Jan 7, 2014·Cell Reports·Valeria VásquezM B Goodman

Mechano-gated ion channels in sensory systems

Oct 15, 2013·Cell·Patrick Delmas, Bertrand Coste

The role of PPK26 in Drosophila larval mechanical nociception

Dec 3, 2014·Cell Reports·Yanmeng GuoZuoren Wang

Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila

Dec 3, 2014·Cell Reports·David A GorczycaYuh Nung Jan

Mating behavior, male sensory cilia, and polycystins in Caenorhabditis elegans

Jul 1, 2014·Seminars in Cell & Developmental Biology·Robert O'HaganMaureen M Barr

Locomotion control of Caenorhabditis elegans through confinement

Jun 28, 2012·Biophysical Journal·Félix LeboisJean-Marc Di Meglio

Caenorhabditis elegans body mechanics are regulated by body wall muscle tone

Apr 21, 2011·Biophysical Journal·Bryan PetzoldB L Pruitt

Epigenetic effect of testosterone in the behavior of C. elegans. A clue to explain androgen-dependent autistic traits?

Mar 14, 2014·Frontiers in Cellular Neuroscience·M Mar Gámez-Del-EstalManuel Ruiz-Rubio

Colored polydimethylsiloxane micropillar arrays for high throughput measurements of forces applied by genetic model organisms

Feb 26, 2015·Biomicrofluidics·Siddharth M KhareSandhya P Koushika

Regulation of food intake by mechanosensory ion channels in enteric neurons

Oct 7, 2014·ELife·William H Olds, Tian Xu

The high threshold mechanotransducer: a status report

Dec 20, 2005·Pain·Jing HuGary R Lewin

Sensory mechanotransduction at membrane-matrix interfaces

Jul 2, 2014·Pflügers Archiv : European journal of physiology·Kate PooleGary R Lewin

The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements

Jun 4, 2014·Pflügers Archiv : European journal of physiology·Jinfeng TengChing Kung

The how and why of identifying the hair cell mechano-electrical transduction channel

Sep 23, 2014·Pflügers Archiv : European journal of physiology·Thomas EffertzAnthony J Ricci

Mechanosensory molecules and circuits in C. elegans

Jul 24, 2014·Pflügers Archiv : European journal of physiology·William R Schafer

GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis

Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chaogu ZhengMartin Chalfie

Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion

Jun 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yanmeng GuoZuoren Wang

Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function

Jun 21, 2016·Neuron·Gyu-Sang HongUhtaek Oh

Plasma membrane mechanical stress activates TRPC5 channels

Apr 8, 2015·PloS One·Bing ShenXiaoqiang Yao

Neuronal substrates of complex behaviors in C. elegans

Jul 19, 2005·Annual Review of Neuroscience·Mario de Bono, Andres Villu Maricq

Mechanosensitive Ion Channels in Caenorhabditis elegans

Jan 1, 2007·Current Topics in Membranes·Dafne Bazopoulou, Nektarios Tavernarakis

Diverse Regulation of Temperature Sensation by Trimeric G-Protein Signaling in Caenorhabditis elegans

Oct 28, 2016·PloS One·Tomoyo UjisawaAtsushi Kuhara

The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth

Sep 23, 2016·Molecular Biology of the Cell·Dean LockheadM B Goodman

Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans

Jan 9, 2016·PLoS Biology·Ithai RabinowitchMillet Treinin

Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

Jan 19, 2017·ELife·Michael KriegM B Goodman

Polymodal Responses in C. elegans Phasmid Neurons Rely on Multiple Intracellular and Intercellular Signaling Pathways

Feb 15, 2017·Scientific Reports·Wenjuan ZouLijun Kang

Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves

Apr 28, 2017·Lab on a Chip·Wei ZhouHairong Zheng

Mechano-sensitivity of ENaC: may the (shear) force be with you

Sep 18, 2007·Pflügers Archiv : European journal of physiology·Martin Fronius, Wolfgang G Clauss

Multisensory neural integration of chemical and mechanical signals

Jun 18, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Juan Antonio Sánchez-Alcañiz, Richard Benton

Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap

Feb 17, 2017·Lab on a Chip·A L NekimkenMichael Krieg

Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans

Jun 30, 2017·Lab on a Chip·Yongmin ChoHang Lu

Ionic basis of a mechanotransduction current in adult rat dorsal root ganglion neurons

Aug 23, 2006·Molecular Pain·Gordon C McCarter, Jon D Levine

On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits

Jan 18, 2018·Lab on a Chip·Yongmin ChoHang Lu

Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels

Oct 21, 2016·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi

Comparing Caenorhabditis elegans gentle and harsh touch response behavior using a multiplexed hydraulic microfluidic device

Sep 16, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Patrick D McClanahanChristopher Fang-Yen

A two-phase response of endothelial cells to hydrostatic pressure

Jun 1, 2018·Journal of Cell Science·Valeria PrystopiukJohannes Fels

A possible unifying principle for mechanosensation

Aug 5, 2005·Nature·Ching Kung

Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress

May 11, 2018·The Journal of Biological Chemistry·Shujie ShiThomas R Kleyman

Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation

Jun 27, 2018·ELife·Mochi LiuAndrew M Leifer

Response to comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans"

Apr 14, 2018·ELife·Andres Vidal-GadeaJonathan T Pierce

The synaptic action of Degenerin/Epithelial sodium channels

Jul 13, 2018·Channels·Alexis S Hill, Yehuda Ben-Shahar

Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans

Oct 12, 2017·MBio·M Fernanda PalominosAndrea Calixto

In vivo tactile stimulation-evoked responses in Caenorhabditis elegans amphid sheath glia

Feb 12, 2015·PloS One·Gang DingLijun Kang

The receptor channel formed by ppk25, ppk29 and ppk23 can sense the Drosophila female pheromone 7,11-heptacosadiene

Oct 23, 2018·Genes, Brain, and Behavior·Tong LiuAike Guo

Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance

Dec 15, 2018·ELife·Luis A Bezares-CalderónGáspár Jékely

MEMS-based force-clamp analysis of the role of body stiffness in C. elegans touch sensation

Apr 20, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bryan PetzoldB L Pruitt

Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons

Jul 14, 2006·Journal of Neurobiology·Christian Frøkjaer-JensenWilliam R Schafer

Primary processes in sensory cells: current advances

Nov 18, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stephan Frings

Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies

Apr 21, 2007·Nature Protocols·Kevin StrangeRebecca Morrison

TRP channels in mechanosensation: direct or indirect activation?

Jun 23, 2007·Nature Reviews. Neuroscience·Adam P Christensen, David P Corey

Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback

Mar 20, 2008·Biological cybernetics·John Bryden, Netta Cohen

Neurosensory mechanotransduction

Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Martin Chalfie

GFP: lighting up life (Nobel Lecture)

Jul 2, 2009·Angewandte Chemie·Martin Chalfie

More than just a barrier: urothelium as a drug target for urinary bladder pain

Aug 12, 2005·American Journal of Physiology. Renal Physiology·Lori A Birder

Lipid-protein interactions along the slit diaphragm of podocytes

Feb 27, 2009·Journal of the American Society of Nephrology : JASN·Bernhard Schermer, Thomas Benzing

Mechanisms of ENaC regulation and clinical implications

Aug 30, 2008·Journal of the American Society of Nephrology : JASN·Vivek Bhalla, Kenneth R Hallows

Chemosensory behavior of semi-restrained Caenorhabditis elegans

Aug 23, 2005·Journal of Neurobiology·Serge FaumontShawn R Lockery

Effects of intracellular pH and Ca2+ on the activity of stretch-sensitive cation channels in leech neurons

Apr 28, 2006·Pflügers Archiv : European journal of physiology·C BarsantiM Pellegrino

ENaC proteins are required for NGF-induced neurite growth

Sep 30, 2005·American Journal of Physiology. Cell Physiology·Heather A DrummondDavid E Stec

Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors

Mar 29, 2019·Proceedings of the National Academy of Sciences of the United States of America·Landi SunXin Liang

Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1

Oct 20, 2005·The Journal of Biological Chemistry·Emmanuel DevalEric Lingueglia

Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance

Oct 22, 2005·The Journal of Biological Chemistry·Dewey C RoyalMonica Driscoll

Touch sensitivity in Caenorhabditis elegans

Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie

Mechanical control of the sense of touch by β-spectrin

Feb 25, 2014·Nature Cell Biology·Michael KriegM B Goodman

Myogenic vasoconstriction in mouse renal interlobar arteries: role of endogenous beta and gammaENaC

Jul 20, 2006·American Journal of Physiology. Renal Physiology·Nikki L Jernigan, Heather A Drummond

ENaC proteins contribute to VSMC migration

Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Samira C GrifoniHeather A Drummond

Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex

Aug 8, 2018·Cold Spring Harbor Perspectives in Medicine·Christopher L Cunningham, Ulrich Müller

Speed and temperature dependences of mechanotransduction in afferent fibers recorded from the mouse saphenous nerve

Sep 26, 2008·Journal of Neurophysiology·Nevena MilenkovicGary R Lewin

Current perspectives on acid-sensing ion channels: new advances and therapeutic implications

May 1, 2010·Expert Review of Clinical Pharmacology·Jacques NoëlEric Lingueglia

How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

May 6, 2019·Genetics·M B Goodman, Piali Sengupta

Multimodal sensory processing in Caenorhabditis elegans

Jun 22, 2018·Open Biology·Athanasios MetaxakisNektarios Tavernarakis

NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels

Feb 26, 2014·The Journal of Biological Chemistry·Shaunak KamatMonica Driscoll

Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing

Aug 14, 2019·ELife·Alessandro SanzeniMassimo Vergassola

The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates

Aug 11, 2011·Molecular Pharmacology·Dominik Wiemuth, Stefan Gründer

Mechanosensitive unpaired innexin channels in C. elegans touch neurons

Sep 26, 2014·American Journal of Physiology. Cell Physiology·Rachele SangalettiLaura Bianchi

Specialized cutaneous Schwann cells initiate pain sensation

Aug 17, 2019·Science·Hind AbdoPatrik Ernfors

Vascular ENaC proteins are required for renal myogenic constriction

May 26, 2005·American Journal of Physiology. Renal Physiology·Nikki L Jernigan, Heather A Drummond

Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8

Apr 26, 2018·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi

Stomatin and sensory neuron mechanotransduction

Oct 19, 2007·Journal of Neurophysiology·Carlos Martinez-SalgadoGary R Lewin

Regulation of the epithelial Na+ channel by paraoxonase-2

Aug 5, 2017·The Journal of Biological Chemistry·Shujie ShiThomas R Kleyman

Progressive recruitment of distal MEC-4 channels determines touch response strength in C. elegans

Sep 20, 2019·The Journal of General Physiology·Samata KattaM B Goodman

Acid-sensing ion channels in sensory signaling

Jan 28, 2020·American Journal of Physiology. Renal Physiology·Marcelo D Carattino, Nicolas Montalbetti

Molecular determinants of desensitization in an ENaC/degenerin channel

Sep 11, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophie RoyStephan Kellenberger

Behavioral Plasticity in the C. elegans Mechanosensory Circuit

Nov 18, 2008·Journal of Neurogenetics·Evan L Ardiel, Catharine H Rankin

Cargo crowding at actin-rich regions along axons causes local traffic jams

Nov 28, 2017·Traffic·Parul SoodSandhya P Koushika

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

Feb 22, 2020·Annual Review of Neuroscience·Peng JinYuh-Nung Jan

Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in Caenorhabditis elegans

Jun 25, 2020·Molecular Biology of the Cell·A L NekimkenM B Goodman

A quantal code for touch intensity in C. elegans

Oct 28, 2019·The Journal of General Physiology·Katherine M Perks, Jonathan T Pierce

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

May 12, 2005·Médecine sciences : M/S·Alex J ParkerChristian Néri

Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor

Sep 17, 2016·Learning & Memory·Evan L ArdielCatharine H Rankin

OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons

May 10, 2018·Scientific Reports·Hu ZhangLijun Kang

Electrophysiological experiments in microgravity: lessons learned and future challenges

Apr 6, 2018·NPJ Microgravity·Simon L WuestMarcel Egli

Genetic Silencing of Fatty Acid Desaturases Modulates α-Synuclein Toxicity and Neuronal Loss in Parkinson-Like Models of C. elegans

Aug 27, 2019·Frontiers in Aging Neuroscience·Malabika MaulikAbel Bult-Ito

Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans

Feb 27, 2020·Nature Communications·Clara L EssmannFilipe Cabreiro

Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited

Dec 30, 2014·Physiological Reviews·Bernard C RossierRomain A Studer

Role of the Membrane for Mechanosensing by Tethered Channels

Jul 9, 2016·Physical Review Letters·Benedikt Sabass, Howard A Stone

The tactile receptive fields of freely moving Caenorhabditis elegans nematodes

Jul 22, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·E A MazzochetteB L Pruitt

Active propagation of dendritic electrical signals in C. elegans

Mar 7, 2019·Scientific Reports·Tomomi ShindouIchiro N Maruyama

The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration

May 10, 2019·APL Bioengineering·Johanna Heureaux-TorresAllen P Liu

A single conserved proline residue determines the membrane topology of stomatin

Nov 27, 2008·The Biochemical Journal·Ivan KadurinStefan Gründer

A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans

Aug 15, 2008·The EMBO Journal·Ying WangLaura Bianchi

The genetic architecture of degenerin/epithelial sodium channels in Drosophila

Mar 2, 2013·G3 : Genes - Genomes - Genetics·Kathleen M ZelleYehuda Ben-Shahar

Determining the biomechanics of touch sensation in C. elegans

Sep 28, 2017·Scientific Reports·Muna ElmiMandayam A Srinivasan

Dietary fatty acids fine-tune Piezo1 mechanical response

Mar 15, 2019·Nature Communications·Luis O RomeroValeria Vásquez

Mechanosensitive ion channel inhibitors promote the stiffening of the plasma membrane of mouse sensory neurons

Oct 1, 2019·Soft Matter·Humberto Reyes-Pardo, Daniel P Sánchez-Herrera

Mechanisms of sensory transduction in the skin

Feb 23, 2007·Nature·Ellen A Lumpkin, Michael J Caterina

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

May 14, 2016·G3 : Genes - Genomes - Genetics·Yushu ChenMartin Chalfie

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit

May 18, 2016·The Journal of Biological Chemistry·Shujie ShiThomas R Kleyman

Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research

Jul 31, 2018·Frontiers in Pediatrics·Henning Hagmann, Paul T Brinkkoetter

Role of mechanosensitive ion channels in the sensation of pain

Apr 7, 2020·Journal of Neural Transmission·Reza Sharif-Naeini

Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

Aug 28, 2018·Neuroscience Bulletin·Huiyin TuYu-Long Li

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole

Sep 25, 2018·Journal of Experimental Neuroscience·Jaime Osuna-LuqueManuel Ruiz-Rubio

Investigation of mechanosensation in C. elegans using light field calcium imaging

Jul 26, 2016·Biomedical Optics Express·Michael ShawMandayam A Srinivasan

Genetic kidney diseases: Caenorhabditis elegans as model system

May 10, 2017·Cell and Tissue Research·Athina Ganner, Elke Neumann-Haefelin

GABAergic motor neurons bias locomotor decision-making in C. elegans

Oct 10, 2020·Nature Communications·Ping LiuZhao-Wen Wang

Mechano-gated channels in C. elegans

Dec 17, 2020·Journal of Neurogenetics·Umar Al-Sheikh, Lijun Kang

Related Concepts

Deg-1 protein, C elegans

Mec-4 protein, C elegans

Kaluril

Electric Conductivity

Meissner's Corpuscle

Cell Surface Proteins

Physical Stimulation

Sodium

Touch Sensation

Sodium Channel

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