The mechanical behaviour of chondrocytes predicted with a micro-structural model of articular cartilage

Biomechanics and Modeling in Mechanobiology
S-K HanWalter Herzog

Abstract

The integrity of articular cartilage depends on the proper functioning and mechanical stimulation of chondrocytes, the cells that synthesize extracellular matrix and maintain tissue health. The biosynthetic activity of chondrocytes is influenced by genetic factors, environmental influences, extracellular matrix composition, and mechanical factors. The mechanical environment of chondrocytes is believed to be an important determinant for joint health, and chondrocyte deformation in response to mechanical loading is speculated to be an important regulator of metabolic activity. In previous studies of chondrocyte deformation, articular cartilage was described as a biphasic material consisting of a homogeneous, isotropic, linearly elastic solid phase, and an inviscid fluid phase. However, articular cartilage is known to be anisotropic and inhomogeneous across its depth. Therefore, isotropic and homogeneous models cannot make appropriate predictions for tissue and cell stresses and strains. Here, we modelled articular cartilage as a transversely isotropic, inhomogeneous (TI) material in which the anisotropy and inhomogeneity arose naturally from the microstructure of the depth-dependent collagen fibril orientation and volumetric frac...Continue Reading

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Citations

Jan 12, 2012·Biomechanics and Modeling in Mechanobiology·E K MooS Federico
Dec 15, 2010·Journal of Biomechanics·Z AbusaraW Herzog
May 3, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Hadi MohammadiWalter Herzog
Feb 5, 2019·History of Psychiatry·Giuseppe A Micheli
Dec 25, 2012·Annals of Biomedical Engineering·Chiara BelliniSalvatore Federico
Jul 29, 2010·Computer Methods in Biomechanics and Biomedical Engineering·Sang-Kuy HanWalter Herzog
Nov 21, 2017·ACS Biomaterials Science & Engineering·Q T NguyenN O Chahine

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