PMID: 9165387Jun 1, 1997Paper

The mechanical properties of simulated collagen fibrils

Journal of Biomechanics
John ParkinsonY Brechet

Abstract

Previous theoretical studies of the mechanical properties of tissues such as skin, bone and tendon, have used approaches based on composite materials and have tended to neglect the contribution of individual microscopic components. In this paper, we examine the relationship between the fine structure of a collagen fibril and its relative tensile strength. Collagen is a fibrous protein which provides associated tissues with the majority of their tensile strength. It is present in the form of elongated structures termed fibrils which are created by the self-assembly of rod-like collagen molecules in an entropy-driven process termed fibrillogenesis. Mutations that alter the primary structure of the collagen molecule, interfere with this assembly process and can lead to the potentially fatal brittle bone disease, osteogenesis imperfecta. Here we investigate the mechanical properties of a range of computer-generated aggregates. The aggregates, created by the diffusion limited aggregation of rods, were subjected to a simple tensile test based on local rules of damage accumulation. In the test, core samples are "extracted' from the aggregates, and the network of particles involved in the transmission of stress resolved. Increasing str...Continue Reading

References

Jan 1, 1992·Annual Review of Medicine·P H Byers, R D Steiner
Jan 1, 1992·Biomaterials·T OkadaY Ikada
Jan 1, 1991·Journal of Biomechanics·R B Martin
Jan 1, 1995·Annual Review of Biochemistry·D J Prockop, K I Kivirikko
Nov 1, 1993·Journal of Biomechanical Engineering·S L WooB A Smith
Apr 1, 1993·Journal of Biomechanics·J F Mammone, S M Hudson

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Citations

Apr 18, 2009·Calcified Tissue International·J W C DunlopR Weinkamer
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Shyh Ming KuoShwu Jen Chang
Dec 25, 2008·Journal of the Royal Society, Interface·P Ciarletta, M Ben Amar
Oct 22, 2010·Journal of the Royal Society, Interface·Fei Hang, Asa H Barber
Nov 1, 1998·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·H LafranceF A Auger
Mar 31, 2005·Journal of Biomechanical Engineering·B E Layton, A M Sastry
May 28, 2011·Journal of the Mechanical Behavior of Biomedical Materials·M A HartmannR Weinkamer
Jul 22, 2008·Biophysical Journal·Zhilei L ShenSteven J Eppell
Jun 13, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·David W SmithBruce S Gardiner
Sep 13, 2011·Biotechnology Progress·Shiva P RaoJuliet A Gerrard
Oct 29, 2015·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·A HoucineS Bessou-Touya
Mar 22, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P H Byers
Aug 21, 2018·Advanced Materials·Anna SorushanovaDimitrios I Zeugolis
Jun 19, 2007·L' Orthodontie française·Agnes S Kamoun-Goldrat
Dec 17, 2004·Physical Review Letters·Richard WeinkamerPeter Fratzl

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