The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection

The Journal of Experimental Medicine
Huji XuM F Good

Abstract

It is thought that both helper and effector functions of CD4(+) T cells contribute to protective immunity to blood stage malaria infection. However, malaria infection does not induce long-term immunity and its mechanisms are not defined. In this study, we show that protective parasite-specific CD4(+) T cells were depleted after infection with both lethal and nonlethal species of rodent PLASMODIUM: It is further shown that the depletion is confined to parasite-specific T cells because (a) ovalbumin (OVA)-specific CD4(+) T cells are not depleted after either malaria infection or direct OVA antigen challenge, and (b) the depletion of parasite-specific T cells during infection does not kill bystander OVA-specific T cells. A significant consequence of the depletion of malaria parasite-specific CD4(+) T cells is impaired immunity, demonstrated in mice that were less able to control parasitemia after depletion of transferred parasite-specific T cells. Using tumor necrosis factor (TNF)-RI knockout- and Fas-deficient mice, we demonstrate that the depletion of parasite-specific CD4(+) T cells is not via TNF or Fas pathways. However, in vivo administration of anti-interferon (IFN)-gamma antibody blocks depletion, suggesting that IFN-gamma...Continue Reading

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B A BiggsG V Brown
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Troye-BlombergP Perlmann
Oct 1, 1989·European Journal of Immunology·C M RzepczykM Honeyman
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodR Hayes
Jan 1, 1983·Annual Review of Immunology·G J Nossal
Jun 25, 1993·Science·A W Taylor-RobinsonF Y Liew
May 2, 1994·Journal of Immunological Methods·A B Lyons, C R Parish
Feb 7, 1997·Cell·S Nagata
Mar 21, 1998·The Journal of Experimental Medicine·D F Tough, J Sprent
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C Hirunpetcharat, M F Good
Mar 20, 1998·Advances in Immunology·J M Penninger, G Kroemer
May 23, 1998·Annual Review of Immunology·M F GoodL H Miller
Jun 8, 1999·Annual Review of Immunology·D WallachM P Boldin
Jul 14, 1999·Immunity·D A HildemanP C Marrack
Aug 17, 1999·Current Opinion in Immunology·M F Good, D L Doolan
Oct 9, 1999·The Journal of Infectious Diseases·H BrownT Taylor
Nov 5, 1999·Annual Review of Microbiology·Y Weinrauch, A Zychlinsky
Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
Apr 27, 2000·Current Opinion in Immunology·G Screaton, X N Xu
Jun 3, 2000·Annual Review of Immunology·D TortorellaH L Ploegh
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H XuM F Good
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J WipasaM F Good

❮ Previous
Next ❯

Citations

Feb 16, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Daniela Santoro RosaEdecio Cunha-Neto
Nov 2, 2013·Trends in Parasitology·Danielle I StanisicMichael F Good
Feb 2, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Padmalaya DasVirander S Chauhan
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tiffany SunRichard Bucala
Jul 4, 2012·The Journal of Experimental Medicine·Yan ZhouChristopher M Walker
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sandra Marcia MuxelMaria Regina D'Império Lima
Jul 16, 2010·The Journal of Clinical Investigation·Alberto Pinzon-CharryMichael F Good
Jul 19, 2013·The Journal of Clinical Investigation·Michael F GoodVirginia McPhun
May 23, 2008·Malaria Journal·Carlos Ocaña-MorgnerAna Rodriguez
Aug 21, 2012·PLoS Neglected Tropical Diseases·Bon-A ChoNam-Hyuk Cho
Feb 20, 2014·PLoS Neglected Tropical Diseases·Vasco RodriguesJérôme Estaquier
Jul 10, 2007·PLoS Pathogens·Michelle N WykesMichael F Good
May 23, 2013·PLoS Pathogens·Steve M TaylorRick M Fairhurst
Feb 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Morris O MakobongoMichael F Good
Feb 18, 2011·Cellular and Molecular Life Sciences : CMLS·Michael F Good
Jan 9, 2016·Parasitology·Danielle I Stanisic, Michael F Good
Oct 3, 2015·Vaccine·Danielle I Stanisic, Michael F Good
Sep 8, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Fouzia Farooq, Elke S Bergmann-Leitner
Jul 13, 2007·Current Opinion in Immunology·Ian A Cockburn, Fidel Zavala
Sep 14, 2004·Immunological Reviews·Michael F GoodMichelle Wykes
May 12, 2005·Immunology·Stephen M Todryk, Michael Walther
Jan 11, 2007·Scandinavian Journal of Immunology·A Ramos-AvilaM Legorreta-Herrera
Jan 28, 2006·Parasite Immunology·R Stephens, J Langhorne
Jul 11, 2006·Immunological Reviews·Kathryn E FouldsRobert A Seder
Jul 23, 2014·European Journal of Immunology·Miranda S OakleySanjai Kumar
Jun 30, 2007·The American Journal of Pathology·Fiona H AmanteChristian R Engwerda
Jul 13, 2004·Current Opinion in Immunology·Aparna Srinivasan, Stephen J McSorley
May 19, 2004·Trends in Parasitology·Eric R James, Douglas R Green

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Sigma Plot

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.