PMID: 589869Sep 1, 1977

The mechanism behind the effect of ALG on platelets in vivo

Clinical and Experimental Immunology
A HenricssonS E Bergentz

Abstract

Antilymphocyte globulin (ALG) and antiplatelet globulin (APG) were injected in dogs whose autologous platelets were labelled with 51Cr. APG injection resulted in almost complete and irreversible disappearance of labelled platelets. ALG produced thrombocytopenia of the same degree, but this was to a large extent reversible. After injection of ALG the platelets were reversibly trapped in the lung during the time when platelet count in peripheral blood was low. Such trapping was not seen after administration of APG. This suggests an antiplatelet mechanism of ALG quite different from that of APG. Platelet-absorbed ALG and non-platelet-absorbed ALG produced thrombocytopenia of the same degree and pattern, making it less likely that the thrombocytopenia was caused by specific platelet antibodies. Also platelet-absorbed APG induced thrombocytopenia, but this was reversible and 'ALG-like'. The mechanism behind the platelet reaction after an ALG injection is well explained in terms of complement C3 adherence and/or Fc receptor-induced aggregation.

Related Concepts

Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine)
Complete Blood Count
Blood Platelets
Canis familiaris
Thrombocytopenia

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
A Henricsson, S E Bergentz
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
A Henricsson, S E Bergentz
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
H E Myrvold, A Brandberg
© 2021 Meta ULC. All rights reserved