The mechanism of action and role of hydrogen sulfide in the control of vascular tone

Nitric Oxide : Biology and Chemistry
Eleni DongóLevente Kiss

Abstract

Our knowledge about hydrogen sulfide (H2S) significantly changed over the last two decades. Today it is considered as not only a toxic gas but also as a gasotransmitter with diverse roles in different physiological and pathophysiological processes. H2S has pleiotropic effects and its possible mechanisms of action involve (1) a reversible protein sulfhydration which can alter the function of the modified proteins similar to nitrosylation or phosphorylation; (2) direct antioxidant effects and (3) interaction with metalloproteins. Its effects on the human cardiovascular system are especially important due to the high prevalence of hypertension and myocardial infarction. The exact molecular targets that affect the vascular tone include the KATP channel, the endothelial nitric oxide synthase, the phosphodiesterase of the vascular smooth muscle cell and the cytochrome c oxidase among others and the combination of all these effects lead to the final result on the vascular tone. The relative role of each effect depends immensely on the used concentration and also on the used donor molecules but several other factors and experimental conditions could alter the final effect. The aim of the current review is to give a comprehensive summar...Continue Reading

Citations

Aug 9, 2018·British Journal of Pharmacology·Joshua B KohlGuenter Schwarz
Apr 11, 2019·Journal of Developmental Origins of Health and Disease·W Tong, D A Giussani
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lin ChangY Eugene Chen
Aug 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Colleen M BartmanChristina Pabelick
Sep 1, 2020·American Journal of Hypertension·Amanda Almeida de Oliveira, Kenia Pedrosa Nunes
Jun 28, 2019·Frontiers in Physiology·Eduardo Nava, Silvia Llorens
Dec 24, 2018·International Journal of Molecular Sciences·Amaal Eman AbdulleDouwe J Mulder
Aug 5, 2020·Bulletin of Experimental Biology and Medicine·G I Lobov
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Adelaeda BarreraNancy L Kanagy
Dec 25, 2019·Nitric Oxide : Biology and Chemistry·Taiming LiuArlin B Blood
Dec 20, 2020·Biomolecules·Eleni Dongó, Levente Kiss
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Shizhen ZhaoHonggang Wang
Jul 3, 2021·Cells·Lukas RoubenneChristelle Guibert
Nov 20, 2019·Analytical Chemistry·Maheshwar Adiraj Iyer, David Eddington

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