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The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase

Biochimica Et Biophysica Acta

Aug 13, 1990

Karin Uta SchallreuterJ Matthew Wood

PMID: 2200526

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Abstract

The nitrosoureas BCNU, CCNU, ACNU, and Fotemustine covalently deactivate thioredoxin reductase, glutathione reductase and ribonucleotide reductase by alkylating their thiolate active sites. Since thioredoxin reductase and glutathione reductase function as alternative electron donors in ...read more

Mentioned in this Paper

Ethers
Glutathione Reductase
Thioredoxin (human)
Antineoplastic Agents
Complex (molecular entity)
Homologous Gene
Ethylenes
Melanoma, Amelanotic
Deoxyribonucleotides
Enzyme Inhibitor Drugs
Paper Details
References
  • References12
  • Citations49
12
  • References12
  • Citations49
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The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase

Biochimica Et Biophysica Acta

Aug 13, 1990

Karin Uta SchallreuterJ Matthew Wood

PMID: 2200526

DOI:

Abstract

The nitrosoureas BCNU, CCNU, ACNU, and Fotemustine covalently deactivate thioredoxin reductase, glutathione reductase and ribonucleotide reductase by alkylating their thiolate active sites. Since thioredoxin reductase and glutathione reductase function as alternative electron donors in ...read more

Mentioned in this Paper

Ethers
Glutathione Reductase
Thioredoxin (human)
Antineoplastic Agents
Complex (molecular entity)

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Paper Details
References
  • References12
  • Citations49
12
  • References12
  • Citations49
12345

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