The mechanism of alpha-adrenergic inhibition of catecholamine release

British Journal of Pharmacology
J CohenY Gutman

Abstract

1 The effect of alpha-adrenoceptor agonists on membrane adenosine triphosphatase (ATPase) activity was studied in membranes from the bovine adrenal medulla and the rat submaxillary gland. 2 alpha-Adrenoceptor agonists (10(-7) to 10(-5) M) enhanced significantly Na,K-ATPase activity but not Mg-ATPase activity in adrenal medulla. This effect was not observed in membranes from phaeochromyocytoma. Phenylephrine (10(-5) M), naphazoline (10(-5) M) and clonidine (10(-5) M) caused a significant increase of the activity of Na,K-ATPase (but not of Mg-ATPase) in the submaxillary gland. The enhancement became more prominent after ligature of the submaxillary duct but disappeared completely after superior cervical ganglionectomy. Thus, the effect of the alpha-adrenoceptor agonists was due to an action on adrenergic nerve terminals in the submaxillary gland. 3 Phenylephrine and naphazoline did not affect 45Ca uptake but enhanced the rate of 45Ca efflux from adrenal medullary slices in vitro. 4 Phenylephrine enhanced the rate of 45Ca efflux from slices of submaxillary gland (with previous ligation of the duct); this was blocked by phentolamine and sympathetic denervation. Therefore phenylephrine was acting on the adrenergic nerve terminals. 5...Continue Reading

References

Jan 1, 1977·Journal of Neural Transmission·Y Gutman, P Boonyaviroj
Apr 28, 1978·Annals of the New York Academy of Sciences·P F Baker
Apr 28, 1978·Annals of the New York Academy of Sciences·E Carafoli, M Crompton
Aug 1, 1977·Canadian Journal of Physiology and Pharmacology·S L Lee, J W Phillis
Feb 15, 1977·Biochemical Pharmacology·P BoonyavirojY Gutman
Jul 15, 1977·European Journal of Pharmacology·G FeurersteinY Gutman
Jan 1, 1969·Biochimica Et Biophysica Acta·Y Gutman, Y Beyth
Dec 15, 1974·Biochemical Pharmacology·T GodfraindN Verbeke
Oct 1, 1974·European Journal of Pharmacology·Y Gutman, P Boonyaviroj
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Nov 1, 1968·British Journal of Pharmacology·W W Douglas

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Citations

May 1, 1985·Circulation Research·C J Homcy, R M Graham

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