PMID: 6402456Mar 15, 1983Paper

The mechanism of augmentation of natural killer cell activity by syngeneic tumor cells: role of macrophage-derived factor in NK boosting

International Journal of Cancer. Journal International Du Cancer
I KawaseC S Henney

Abstract

The role of natural killer (NK) cells in controlling tumor growth was investigated using an NK-susceptible (c127v-IC2) and an NK-insusceptible (c127av) subline of the lymphoma L5178Y. Syngeneic DBA/2 mice inoculated intraperitoneally with c127v-IC2 tumor cells survived significantly longer than did c127av-bearing mice. Similarly, c127v-IC2, but not c127av tumor cells, were found to augment NK activity of spleen and peritoneal exudate cells in both DBA/2 and BALB/c nu/nu mice when inoculated into the peritoneal cavity. C127v-IC2 tumor cells incubated with either DBA/2 or BALB/c nu/nu spleen cells in vitro boosted NK activity and induced the production of gamma-type interferon (IFN), whereas incubation with c127av tumor cells induced neither NK activity nor IFN. Two kinds of cells cooperated in the production of IFN in response to c127v-IC2 tumor cells, namely, cells which were nonadherent, bore asialo-GM1, NK-1.2 and a low level of Thy-1.2 antigen and thus closely resembled NK cells, and those which were adherent and phagocytic and lacked both asialo-GM1 and NK-1.2 markers, presumably macrophages. Further analysis strongly suggested that c127-v-IC2 tumor cells stimulate macrophages to produce factor(s) which can induce the produ...Continue Reading

References

Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·H J Dawkins, G R Shellam
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·R B HerbermanJ Y Djeu
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 1, 1980·The Journal of Experimental Medicine·J Y DjeuR B Herberman
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·G R ShellamH J Dawkins
Sep 1, 1981·The Journal of Experimental Medicine·N MinatoB R Bloom
May 15, 1982·International Journal of Cancer. Journal International Du Cancer·I KawaseC S Henney

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Citations

Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·A GrönbergG Klein
Mar 1, 1985·Cellular Immunology·E T Bloom, J T Babbitt
Oct 20, 2004·Critical Reviews in Microbiology·Nidhi AhujaRakesh Bhatnagar

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