PMID: 9551092Apr 29, 1998Paper

The mechanism of Ca2+ release from the SR of permeabilised guinea-pig and rat ureteric smooth muscle

Biochimica Et Biophysica Acta
T V BurdygaS Wray

Abstract

Recent work has indicated that there is a major difference in the Ca2+ store of smooth muscle from rat and guinea-pig ureter; with the rat store being agonist-sensitive but ryanodine insensitive and the guinea-pig store being ryanodine sensitive but agonist insensitive [Th. V. Burdyga, M.J. Taggart, S. Wray, J. Physiol. 489 (1995) 327-335]. We have therefore examined directly the mechanism of Ca2+ release from the internal Ca2+ store (SR). Following permeabilisation with alpha-toxin or beta-escin the SR was Ca(2+)-loaded before application of carbachol or caffeine. Only carbachol evoked a transient contraction in rat ureter. The carbachol-induced contraction was blocked by heparin and cyclopiazonic acid (CPA) but not ryanodine. Only caffeine produced contraction in guinea-pig ureter, and this was blocked by ryanodine. Direct application of IP3 caused a small transient contraction in rat but not guinea-pig ureter. We conclude that rat ureter possesses only an IP3 sensitive store while guinea-pig ureter only has a ryanodine sensitive store.

References

Mar 1, 1972·The Journal of Cell Biology·C E DevineA P Somlyo

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Citations

Nov 10, 2006·Pflügers Archiv : European journal of physiology·Qing-Hua LiuYong-Xiao Wang
Jun 22, 2000·The Biochemical Journal·F X BoittinJ Mironneau
Jun 12, 2009·Clinical and Experimental Pharmacology & Physiology·Richard J LangHikaru Suzuki
Mar 27, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Damodaran NarayananJonathan H Jaggar
Jan 21, 2010·Physiological Reviews·Susan Wray, Theodor Burdyga
Dec 17, 2004·Pharmacological Reviews·Régent LaporteIsmail Laher
Oct 31, 2006·Cell Calcium·John G McCarronThomas C Muir
Mar 17, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Karen NobleSusan Wray

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