The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits.

Anesthesia and Analgesia
Paul S PagelDorothee Weihrauch

Abstract

Helium produces preconditioning against myocardial infarction by activating prosurvival signaling, but whether nitric oxide (NO) generated by endothelial NO synthase plays a role in this phenomenon is unknown. We tested the hypothesis that NO mediates helium-induced cardioprotection in vivo. Rabbits (n = 62) instrumented for hemodynamic measurement were subjected to a 30-min left anterior descending coronary artery occlusion and 3 h reperfusion, and received 0.9% saline (control) or three cycles of 70% helium-30% oxygen administered for 5 min interspersed with 5 min of an air-oxygen mixture before left anterior descending coronary artery occlusion in the absence or presence of pretreatment with the nonselective NOS inhibitor N-nitro-l-arginine methyl ester (L-NAME; 10 mg/kg), the selective inducible NOS inhibitor aminoguanidine hydrochloride (AG; 300 mg/kg), or selective neuronal NOS inhibitor 7-nitroindazole (7-NI; 50 mg/kg). In additional rabbits, the fluorescent probe 4,5-diaminofluroscein diacetate (DAF-2DA) and confocal laser microscopy were used to detect NO production in the absence or presence of helium with or without L-NAME pretreatment. Helium reduced (P < 0.05) infarct size (24% +/- 4% of the left ventricular area a...Continue Reading

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Citations

Dec 8, 2011·Medical Gas Research·Wenwu LiuJohn H Zhang
Aug 7, 2013·Medical Gas Research·Carlos J Berganza, John H Zhang
Jan 12, 2013·Medical Gas Research·Wenwu LiuXuejun Sun
Feb 2, 2013·Medical Gas Research·Ecem EsencanJohn H Zhang
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel
Feb 24, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S PagelDorothee Weihrauch
May 5, 2011·Neuroscience Letters·Yi PanW Michael Panneton
May 13, 2010·Anesthesiology·Gezina T M L OeiBenedikt Preckel
Dec 12, 2012·Anesthesiology·Kirsten F SmitBenedikt Preckel
May 29, 2014·The Journal of Biological Chemistry·Stephen R ThomMing Yang
Apr 17, 2009·Current Opinion in Anaesthesiology·Stefan G De HertWolfgang S Schlack
Feb 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·R HuhnB Preckel
Nov 5, 2014·British Journal of Pharmacology·Kirsten F SmitBenedikt Preckel
Dec 21, 2019·Intensive Care Medicine Experimental·Nina C Weber, Benedikt Preckel

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