The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1

The British Journal of Dermatology
L ManakaGenji Imokawa

Abstract

Seborrhoeic keratosis (SK) is a benign epidermal tumour with increased pigmentation. We have recently demonstrated that increased secretion of endothelin (ET)-1, a strong keratinocyte-derived mitogen and melanogen for human melanocytes, is intrinsically involved in the hyperpigmentation mechanism of SK. To examine whether the increased ET secretion results from cytokines that induce ET production and/or from differences in the processing of ET that lead to its final active, secreted form. We used immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) to determine whether ET-inducing enzymes and/or cytokines are also highly expressed in SK. RT-PCR of mRNAs encoding interleukin (IL)-1alpha, tumour necrosis factor (TNF)-alpha and endothelin-converting enzyme (ECE)-1alpha demonstrated that there is an increased expression of TNF-alpha and ECE-1alpha mRNAs in SK, whereas the IL-1alpha transcript is rather downregulated in SK compared with that in perilesional normal epidermis. In parallel, immunohistochemical analysis of SK revealed marked immunostaining for TNF-alpha in basaloid cells at lower levels of the epidermis and in basal cells, and for ECE-1alpha in most basaloid and basal cells in comparison wit...Continue Reading

References

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Citations

Aug 6, 2013·American Journal of Clinical Dermatology·Carlos R Camara-Lemarroy, Julio C Salas-Alanis
May 29, 2004·The American Journal of Dermatopathology·Eckhard FiedlerPeter Helmbold
Feb 5, 2010·Pigment Cell & Melanoma Research·Amy Saldana-Caboverde, Lidia Kos
Dec 21, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Philippe Paquet, Gérald E Piérard
May 29, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Vierkötter
Jun 11, 2005·Experimental Dermatology·Cheng-Che E LanHsin-Su Yu
May 13, 2005·Photodermatology, Photoimmunology & Photomedicine·Andrew BurdVincent K M Poon
Apr 12, 2011·Histopathology·Jag Bhawan
Jun 12, 2010·The Journal of Dermatology·Tsuyoshi MitsuishiSeiji Kawana
Jul 26, 2013·BMB Reports·Ping ZhangTianwen Gao
Feb 29, 2020·Cells·Stéphane Mélik ParsadaniantzChristophe Baudouin
Jul 1, 2020·Micromachines·Renhao LuEsak Lee
Feb 2, 2013·PloS One·Severin Reinhard HeynenChristian Grimm
Aug 24, 2013·International Journal of Dermatology·Scott DeckelbaumDavid Horowitz
Jul 3, 2021·International Journal of Molecular Sciences·Shilpi Goenka, Sanford R Simon
May 12, 2011·Biochemical and Biophysical Research Communications·Masakazu KuritaKiyonori Harii

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