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The mechanism of inhibition of ureogenesis by acidosis

Bioscience Reports

Oct 1, 1984

J P MonsonR D Cohen

PMID: 6518274

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Abstract

In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes, from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mito...read more

Mentioned in this Paper

Gluconeogenesis
Carmol
Ornithine Monoacetate, (L)-Isomer
Citrulline
Mitochondria, Liver
Abufne
Lactates
Mitochondria
Carbamoyl Phosphate Biosynthetic Process
Metabolic Inhibition
Paper Details
References
  • References4
  • Citations7
1
  • References4
  • Citations7
1

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The mechanism of inhibition of ureogenesis by acidosis

Bioscience Reports

Oct 1, 1984

J P MonsonR D Cohen

PMID: 6518274

DOI:

Abstract

In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes, from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mito...read more

Mentioned in this Paper

Gluconeogenesis
Carmol
Ornithine Monoacetate, (L)-Isomer
Citrulline
Mitochondria, Liver
Abufne
Lactates
Mitochondria
Carbamoyl Phosphate Biosynthetic Process
Metabolic Inhibition

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Kidney International

Ammonia partitioning between glutamine and urea: interorgan participation in metabolic acidosis

Kidney InternationalNovember 1, 1981
V PhromphetcharatT C Welbourne
European Journal of Clinical Investigation

The effects of administrations of HCl, NH4Cl and NH4HCO3 on the excretion of urea and ammonium in man

European Journal of Clinical InvestigationDecember 1, 1977
A FineE Bourke
Paper Details
References
  • References4
  • Citations7
1
  • References4
  • Citations7
1

Download from

PubMed
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