PMID: 4287485Mar 1, 1966Paper

The mechanism of insulin action. The effect of insulin action. The effect of insulin on the allosteric properties on intracellular haemoglobin

The Journal of Physiology
T L Dormandy

Abstract

1. The results in three experimental series have suggested that a number of modifying factors must be taken into account in considering the allosteric behaviour of structurally bound intracellular, as distinct from free, haemoglobin. It seems that intracellular haemoglobin maintains its maximal internal stability during oxygen uptake and release by configurational changes which involve not only its acid-base-binding groups but also partial electron-transfer complexes with the stromal macro-molecular framework. Conversely, the affinity of intracellular haemoglobin for oxygen reflects the positive or negative electron pressures prevailing at the haemoglobin-stromal complexing sites.2. Active glucolysis in intact cells entails continuous poising of metabolic redox potential changes by the stromal material (in the same way as it entails continuous buffering of acid metabolic products). The consequent shifts in stromal redox potential and capacity are transmitted to haemoglobin and are reflected in a changing affinity for oxygen.3. The behaviour of the intracellular haemoglobin-stromal complex is further modified by extracellular electron donors and acceptors and by the capacity of the cell/extracellular interface to act as an elect...Continue Reading

Citations

Oct 1, 1969·Respiration Physiology·C BauerH Bartels
Feb 28, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nadezhda N BarvitenkoOguz K Baskurt

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