The mechanism of ovulation inhibition by triamcinolone acetonide

The Journal of Clinical Endocrinology and Metabolism
G R CunninghamM Oliver

Abstract

A single dose of 25 mg triamcinolone acetonide, when given on day 1 or 2 of the menstrual cycle, inhibits ovulation. To examine the mechanism of this action, daily determinations of plasm FSH, LH, estrone plus estradiol (E1 + E2), and progestins were performed. Some subjects also received a single dose of LH-RH or hCG on cycle day 15 or clomiphene citrate on days 5-9. Triamcinolone acetonide itself caused variable suppression of plasma estrogens, loss of the mid-cycle gonadotropin surge, and a deficient or absent rise in plasma progestins. Impaired secretion of estrogen did not seem to be due to low gonadotropin levels. FSH and LH responses to LH-RH were adequate in relation to prevailing estrogen levels. Four of six women treated with clomiphene responded with plasma progestin levels which exceed 8 ng/ml. Triamcinolone acetonide seems to affect the hypothalamic-pituitary-ovarian axis mainly by hypothalamic suppression and possibly by a direct effect on the ovary as well.

Citations

Jul 1, 1997·Journal of Assisted Reproduction and Genetics·D BiderI Tur-Kaspa
Aug 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jason G Hirsch, Eric Shen-Zen Hsu
Jul 3, 2013·American Journal of Obstetrics and Gynecology·Elizabeth Suh-BurgmannJames Mura
Nov 23, 2016·Orthopedics·Emily M BrookElizabeth G Matzkin
Jul 7, 2017·Nature Reviews. Rheumatology·Monika Østensen
Nov 3, 2006·American Journal of Physical Medicine & Rehabilitation·Todd P StitikPatrick M Foye

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