The mechanism of phosphorus as a cardiovascular risk factor in CKD.

Journal of the American Society of Nephrology : JASN
Suresh MathewKeith A Hruska

Abstract

Hyperphosphatemia and vascular calcification have emerged as cardiovascular risk factors among those with chronic kidney disease. This study examined the mechanism by which phosphorous stimulates vascular calcification, as well as how controlling hyperphosphatemia affects established calcification. In primary cultures of vascular smooth muscle cells derived from atherosclerotic human aortas, activation of osteoblastic events, including increased expression of bone morphogenetic protein 2 (BMP-2) and the transcription factor RUNX2, which normally play roles in skeletal morphogenesis, was observed. These changes, however, did not lead to matrix mineralization until the phosphorus concentration of the media was increased; phosphorus stimulated expression of osterix, a second critical osteoblast transcription factor. Knockdown of osterix with small interference RNA (siRNA) or antagonism of BMP-2 with noggin prevented matrix mineralization in vitro. Similarly, vascular BMP-2 and RUNX2 were upregulated in atherosclerotic mice, but significant mineralization occurred only after the induction of renal dysfunction, which led to hyperphosphatemia and increased aortic expression of osterix. Administration of oral phosphate binders or intr...Continue Reading

Associated Clinical Trials

Feb 15, 2019·Orlando M. Gutierrez, MD, MMSc

References

Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·H M HoffmannJ L Stein
Apr 1, 1993·The Journal of Clinical Investigation·K BoströmL L Demer
May 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D M EricksonZ Schwartz
Sep 25, 1998·The Journal of Biological Chemistry·M Macías-SilvaJ L Wrana
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·G R BeckE Moran
Sep 29, 2000·Circulation Research·S JonoC M Giachelli
Jan 3, 2001·American Journal of Physiology. Renal Physiology·T D PiscioneN D Rosenblum
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C R DhoreM J Daemen
Feb 19, 2002·Journal of the American College of Cardiology·Paolo RaggiGlenn M Chertow
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Terence M DohertyTripathi B Rajavashisth
Jun 26, 2002·Kidney International·Glenn M ChertowUNKNOWN Treat to Goal Working Group
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kerry L TysonCatherine M Shanahan
Mar 13, 2003·Kidney International·Sharon M MoeNeal X Chen
May 23, 2003·Journal of the American Society of Nephrology : JASN·Matthew R DaviesKeith A Hruska
Aug 20, 2003·The Journal of Biological Chemistry·Su-Li ChengDwight A Towler
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Sep 10, 2003·Biochemical and Biophysical Research Communications·Mi-Hye LeeHyun-Mo Ryoo
Jan 20, 2004·Seminars in Nephrology·Neal X Chen, Sharon M Moe
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Richard J LundKeith A Hruska
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
May 8, 2004·American Heart Journal·Astrid Trion, Arnoud van der Laarse
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 12, 2004·American Journal of Physiology. Renal Physiology·Jürg BiberHeini Murer
Dec 24, 2004·Journal of the American Society of Nephrology : JASN·Bryan KestenbaumDennis L Andress
Apr 9, 2005·Journal of the American Society of Nephrology : JASN·Yelena SlininAllan J Collins
Apr 21, 2005·The Journal of Clinical Investigation·Jian-Su ShaoDwight A Towler
Jul 26, 2005·Nature Medicine·Takako KogaHiroshi Takayanagi
Nov 29, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Keiichi TamagakiMasafumi Fukagawa
Dec 22, 2006·Journal of the American Society of Nephrology : JASN·Suresh MathewKeith A Hruska
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Tomas Berl, William Henrich

❮ Previous
Next ❯

Citations

Oct 7, 2009·Calcified Tissue International·Nozomu HosakaTadao Akizawa
Apr 30, 2013·Drugs·Fabio Malberti
Sep 7, 2011·Nature Reviews. Nephrology·Alastair J HutchisonPaul E C Brenchley
Jul 20, 2011·Nature Reviews. Nephrology·Markus KettelerGeorg Schlieper
Aug 15, 2012·Nature Reviews. Rheumatology·Christos E LampropoulosDavid P D'Cruz
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ellen NevenVeerle Persy
Jan 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aristeidis StavroulopoulosMichael J D Cassidy
Mar 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus OlgaardJustin Silver
May 27, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paola CiceriMario Cozzolino
Jul 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takashi ShigematsuUNKNOWN COLC Research Group
Nov 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge B Cannata-AndiaKeith Hruska
Dec 17, 2008·Current Opinion in Rheumatology·Thomas Bardin, Pascal Richette
Jun 29, 2010·Current Opinion in Nephrology and Hypertension·Anna L Zisman, Myles Wolf
Jan 20, 2011·Current Opinion in Nephrology and Hypertension·Orlando M Gutiérrez
Jul 12, 2012·International Journal of Clinical Practice·R HajhosseinyD J Goldsmith
May 5, 2012·Nephron. Clinical Practice·João M Frazão, Teresa Adragão
Sep 3, 2011·Circulation Research·Catherine M ShanahanCecilia M Giachelli
Aug 20, 2011·Circulation Research·Frank RutschRobert Terkeltaub
Aug 11, 2012·PloS One·Afsaneh RangianiJian Q Feng
May 2, 2008·Journal of the American Society of Nephrology : JASN·Suresh MathewKeith A Hruska
May 9, 2009·Journal of the American Society of Nephrology : JASN·Taku KokuboEric T Choi
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Tamara IsakovaMyles Wolf
Dec 1, 2010·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Sep 18, 2010·Journal of the American Society of Nephrology : JASN·Orlando M GutiérrezUNKNOWN CRIC Study Group
Aug 14, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Yi-Wen ChiuRajnish Mehrotra
Sep 10, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Emanuel ZittUlrich Neyer
Aug 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Susan L FurthBradley A Warady
Feb 27, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Nazanin NooriJoel D Kopple
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Shu-Zhi WangZheng-Hong Qin
Sep 21, 2013·Journal of Bone and Mineral Metabolism·Takaaki OkamotoToshiro Fujita
Sep 10, 2014·Journal of Endocrinological Investigation·A BianM C Hu
Sep 4, 2013·Drugs in R&D·Aurélie LengletZiad A Massy
Jun 1, 2012·Nutrition Reviews·Eiji TakedaYutaka Taketani
Sep 4, 2010·Clinical and Experimental Nephrology·Takashi Shigematsu, UNKNOWN Lanthanum Carbonate Research Group
Jan 10, 2013·Hospital Practice·Venkatesh Kumar AriyamuthuKunal Chaudhary
Jun 11, 2014·Expert Opinion on Pharmacotherapy·Francesco LocatelliGoce Spasovski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

© 2022 Meta ULC. All rights reserved