The mechanism of protein kinase C activation.

Trends in Neurosciences
K P Huang

Abstract

Protein kinase C (PKC) consists of a family of closely related enzymes highly concentrated in the CNS. These enzymes respond to the second messengers calcium (Ca2+) and diacylglycerol (DAG), to express their activities at membrane locations. Each member of this enzyme family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC in the nervous system has been implicated in the regulation of neurotransmitter release, ion channels, growth and differentiation, and neural plasticity. It is believed that an increase in the intracellular concentration of Ca2+ triggers the association of a group of PKC isozymes with the membrane where DAG interacts with PKC to stimulate the enzyme activity. Stimulation of PKC at the cellular membrane is, therefore, dependent upon the duration and magnitude of the DAG signal. The association of PKC with the membrane may also lead to a conversion of the enzyme into an effector-independent form for a sustained activation after the Ca2+ and DAG signals dissipate. Activation of PKC results in the phosphorylation of cellular proteins; however, the physiological substrates of this enzyme in the nervous system are still poorly character...Continue Reading

References

Feb 13, 1986·Biochemical and Biophysical Research Communications·A HanssonB Samuelsson
Aug 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J H Exton
Mar 15, 1989·Biochemical and Biophysical Research Communications·E KobayashiT Tamaoki
Oct 1, 1988·Trends in Neurosciences·K P CampbellA H Sharp
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y OnoY Nishizuka
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B L ChanA R Saltiel
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K HosodaY Nishizuka
Jul 1, 1988·The American Journal of Physiology·A R Saltiel, P Cuatrecasas
Feb 10, 1987·Brain Research·R C MalenkaR A Nicoll
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J K WangP Greengard
Mar 31, 1989·Biochemical and Biophysical Research Communications·F K ZhaoR Y Chuang
Dec 19, 1986·Science·P W MajerusD B Wilson
Jan 30, 1987·Biochemical and Biophysical Research Communications·H KaseM Kaneko
Jan 13, 1987·Biochemistry·M D Bazzi, G L Nelsestuen
Apr 15, 1988·Biochemical and Biophysical Research Communications·M D Bazzi, G L Nelsestuen
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J M BarabanB E Alger
Oct 14, 1988·Biochemical and Biophysical Research Communications·A TestoriA W Murray
Jan 1, 1987·Annual Review of Biochemistry·M J Berridge
Mar 30, 1988·Biochemical and Biophysical Research Communications·Y KosakaY Nishizuka
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C R GerfenS G Rhee
Dec 31, 1987·Biochemical and Biophysical Research Communications·F L HuangK P Huang
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B R GanongR M Bell
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K A AlbertP Greengard
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K P HuangF L Huang
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Jaken, S C Kiley

❮ Previous
Next ❯

Citations

May 1, 1993·Journal of Cellular Biochemistry·M C ShoshanM Thelestam
May 1, 1993·Journal of Cellular Biochemistry·M C ShoshanM Thelestam
Aug 1, 1990·Pflügers Archiv : European journal of physiology·F V BrozovichK G Morgan
Feb 1, 1994·Pflügers Archiv : European journal of physiology·N V Marrion
Apr 1, 1995·Pflügers Archiv : European journal of physiology·G CharpentierF Fournier
Jun 1, 1992·Pflügers Archiv : European journal of physiology·E BourinetJ Nargeot
Aug 1, 1991·The Histochemical Journal·R RoivainenJ Koistinaho
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·X J WangJ DiGiovanni
Feb 22, 1991·Pharmaceutisch Weekblad. Scientific Edition·M Beukers, E W Boddeke
Oct 1, 1994·Agents and Actions·M D EstévezL M Botana
Apr 23, 1999·Invertebrate Neuroscience : in·H CruzblancaF J Alvarez-Leefmans
Nov 26, 1990·Brain Research·J B DennyD L Armstrong
Aug 6, 1992·European Journal of Pharmacology·S T Abraham, P J Rice
Jun 1, 1993·Mechanisms of Ageing and Development·H MatsushimaH Hidaka
Nov 1, 1993·Mechanisms of Ageing and Development·B A SmartH J Cohen
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·K MorimotoK Sato
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·K SpielerW Haefely
Jan 1, 1994·Developmental and Comparative Immunology·K G Burnett, L K Schwarz
Dec 1, 1991·Pharmacology & Therapeutics·J A Court, E K Perry
Dec 1, 1990·Trends in Pharmacological Sciences·L BoscáM J Díaz-Guerra
Apr 7, 1992·Biochimica Et Biophysica Acta·R Zidovetzki, D S Lester
Jan 13, 1994·Biochimica Et Biophysica Acta·C J Hillard, J A Auchampach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.