PMID: 7082908May 1, 1982Paper

The mechanism of the positive inotropic action of ketamine on isolated atria of the rat

British Journal of Pharmacology
S BarrigónT Tejerina

Abstract

1 The effect of ketamine (10-7 M-5 X10-4 M) on electrical and mechanical properties of isolated atria of the rat was investigated. 2. On spontaneously beating right atria, ketamine produced a dose-dependent positive inotropic effect which was accompanied by a progressive reduction in atrial rate. 3 In electrically driven left atria, ketamine produced a dose-dependent positive inotropic effect which was accompanied by a parallel increase in df/dtmax and by a prolongation in the time to peak tension and in the time for total concentration. The positive inotropic effect occurred concomitantly with an increase in the height and duration of the plateau phase of the action potential of atrial fibres. 4 The positive inotropic effect of ketamine varied with the concentration of Ca and Na in the bathing media and the rate of stimulation. 5 Ketamine decreased post-extrasystolic potentiation and the amplitude-interval relationship. 6 The positive inotropic effect of ketamine was inhibited by verapamil (10-6 M) and by caffeine (4 X10-3 M). 7 Ketamine, 5 X10-5M and 10-4M, increased 45Ca uptake in electrically driven left atria. At 10-4M and 5 X10-4M, ketamine also increased 45Ca efflux. 8 These results suggest that ketamine produces its pos...Continue Reading

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Citations

Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G E HillC W Whitten
Nov 11, 1983·European Journal of Pharmacology·T TejerinaJ Tamargo
Jun 18, 1991·European Journal of Pharmacology·F Pérez-VizcainoJ Tamargo
Mar 1, 1996·Acta Anaesthesiologica Scandinavica·T A Thurston, B P Mathew
May 1, 1997·Acta Anaesthesiologica Scandinavica·Y C LiG Bjerneroth
Mar 1, 1993·Disease-a-month : DM·E BenjaminT J Iberti
Feb 1, 1987·British Journal of Pharmacology·J J Diez, J Tamargo
Nov 1, 1985·British Journal of Pharmacology·J J DiezC Valenzuela
Apr 1, 1986·British Journal of Pharmacology·S Barrigón, J Tamargo
May 21, 1998·The Journal of Veterinary Medical Science·Y HaraH Kondo

Related Concepts

Cardiac Arrhythmia
Calcium
Drug Interactions
Pulse Rate
Ketamine Hydrochloride
Resting Potentials
Myocardial Contraction
August Rats

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