PMID: 9184815May 1, 1997Paper

The mechanism of the relaxing effect of ascorbic acid in guinea pig isolated tracheal muscle

General Pharmacology
E Sipahi, Z S Ercan

Abstract

1. The effect of ascorbic acid was studied in the guinea pig isolated tracheal muscle. 2. Ascorbic acid with relatively higher concentrations produced a dose-dependent relaxation in tracheal muscle submaximally precontracted with KCl, histamine, and carbachol. 3. Removing the epithelium did not significantly alter the relaxing effect of ascorbic acid in histamine- and KCl-precontracted strips. 4. The relaxing effect of ascorbic acid is stronger in carbachol-precontracted epithelium-denuded strips than in epithelium-intact strips. 5. Indomethacin, but not L-NAME, partially inhibited the relaxing effect of ascorbic acid. 6. These results indicate that the relaxation induced by ascorbic acid in guinea pig isolated tracheal muscle does not fully depend on the presence of epithelium but is partially mediated by the production of prostanoids from smooth muscle.

References

Nov 1, 1979·The Journal of Pharmacy and Pharmacology·J Emmerson, D Mackay
Jan 1, 1990·General Pharmacology·D Raeburn
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Nov 19, 1986·European Journal of Pharmacology·M Ilhan, I Sahin
Sep 23, 1986·European Journal of Pharmacology·D W HayJ S Fedan
Mar 1, 1986·British Journal of Pharmacology·M C Holroyde
Nov 1, 1985·British Journal of Pharmacology·P J BarnesJ B Palmer

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Citations

Nov 25, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mohammad Hossein Boskabady, Toctam Ziaei
Jan 1, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Harri Hemilä
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G L CasoniA Papi
Oct 17, 2013·American Journal of Respiratory Cell and Molecular Biology·Narayanan VenkatesanMara S Ludwig

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