The mechanism of venous valve closure in normal physiologic conditions

Journal of Vascular Surgery
Fedor LurieBo Eklof

Abstract

The purpose of this investigation was to study the mechanism of venous valve closure in physiologic conditions in situ, particularly the clarification of the role of reversed flow through the valve in the closure of the valve cusps. A second purpose was the study of temporal relations between movements of the valve cusps, changes in geometry of venous sinus, and blood flow. Twelve healthy volunteers underwent examination with duplex ultrasound scanning. The time relationship between the flow and venous valve movements was analyzed on the basis of real time ultrasound scan records of the saphenofemoral junction. The size and shape of the common femoral vein and the proximal greater saphenous vein were measured with a planimeter. Reverse flow below the valve was registered in only one of the 12 studied subjects. The maximum peak velocity of the reverse flow in this case was 0.8 cm/s and the duration was 0.2 seconds. The reverse flow was registered just before and just after valve closure. The mean duration of the outflow wave below the valve was 816 +/- 57 ms, which was not significantly different from the time of the valve cycle (819 +/- 55 ms; P =.864). The closure of the valve coincided with the decrease of the flow velocities...Continue Reading

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Citations

Jan 19, 2012·Histochemistry and Cell Biology·Bianca HemmeryckxH R Lijnen
Dec 1, 2006·Journal of Biological Physics·Gavin A Buxton, Nigel Clarke
Apr 20, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ranjeet M DongaonkarRandolph H Stewart
Feb 14, 2015·JACC. Cardiovascular Imaging·Partho P Sengupta, Jagat Narula
Mar 8, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Fedor Lurie
Jun 6, 2009·Journal of Vascular Surgery·Dominic MühlbergerErich Brenner
Aug 26, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·W-H TienG S Kassab
Aug 12, 2008·Journal of Vascular Surgery·Dominic MühlbergerErich Brenner
Nov 7, 2003·Journal of Vascular Surgery·Fedor LurieDarcy Kessler
Sep 23, 2011·Phlebology·C Tasch, E Brenner
Sep 19, 2018·International Journal for Numerical Methods in Biomedical Engineering·Sara Calandrini, Eugenio Aulisa
Mar 31, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ranjeet M DongaonkarChristopher M Quick
May 2, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Gert Jan de Borst, Frans L Moll
Feb 23, 2020·Science Translational Medicine·Sophie C HofferberthPedro J Del Nido
Jul 20, 2021·Research and Practice in Thrombosis and Haemostasis·Jessica LinKeith B Neeves
Jun 19, 2018·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Henry Y ChenGhassan S Kassab

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