PMID: 16519008Mar 8, 2006Paper

The mechanisms and functions of activity-dependent long-term potentiation of intrinsic excitability

Reviews in the Neurosciences
Jun Xu, J Kang

Abstract

The efficiency of neural circuits can be enhanced not only by increasing synaptic strength but also by increasing neuronal intrinsic excitability. Three major types of activity-dependent long-term potentiation of intrinsic excitability (LTP-IE) have been well defined: decreased action potential (AP) threshold, reduced afterhyperpolarization (AHP), and attenuated dendritic propagation. The ionic basis and induction pathways for these three types of LTP-IE have been largely revealed recently. These intrinsic plasticities and their cooperation enrich the functions fulfilled by neurons, and may serve as a supplementary mechanism for learning and memory.

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Jun 2, 2007·Nutritional Neuroscience·Bernard G SchreursD Larry Sparks
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