PMID: 3768467Aug 1, 1986Paper

The mechanisms of interaction between furanochromones and DNA. A heteronuclear Overhauser effect study on the khellin-thymidine model system

Biophysical Chemistry
N NiccolaiP Martelli

Abstract

The furanochromones khellin and visnagin have been characterised by 1H and 13C mono- and bidimensional NMR spectroscopies. Their strong affinity with DNA was experimentally confirmed by the complete disappearance of the furano-chromones' NMR signals upon additions of DNA. An intermolecular interaction between furanochromones and the thymidyl moieties of DNA, stabilized by the formation of a hydrogen bond between the thymidyl NH hydrogen and the C = O group of khellin or visnagin, is here proposed. This is suggested by the strong donor-acceptor behavior of these two molecular moieties, as pointed out by a selective 1H-13C Overhauser effect study of the khellin-thymidine model system.

References

Mar 15, 1985·Science·D A PearlmanS H Kim
Nov 14, 1984·Biochemical and Biophysical Research Communications·N NiccolaiW A Gibbons

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Citations

Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·L TrabalziniE Sage
Dec 1, 1989·Photochemistry and Photobiology·D Averbeck
Jul 30, 2009·Nucleic Acids Research·Emmanouil Rampakakis, Maria Zannis-Hadjopoulos
Oct 27, 2015·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Kamila DurisovaAles Tichy
Jun 22, 2018·The EMBO Journal·Elisa GobbiniMaria Pia Longhese
Nov 15, 2012·Mass Spectrometry Reviews·Catherine Silvestri, Jennifer S Brodbelt
May 3, 2020·Pharmaceutics·Joana PereiraJoana Marto
Feb 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·F Dall'Acqua, P Martelli

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