The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects.

Signal Transduction and Targeted Therapy
Weiwei TangXuehao Wang

Abstract

Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC), sorafenib is currently an effective first-line therapy. Unfortunately, the development of drug resistance to sorafenib is becoming increasingly common. This study aims to identify factors contributing to resistance and ways to mitigate resistance. Recent studies have shown that epigenetics, transport processes, regulated cell death, and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression. This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients.

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Citations

Dec 11, 2020·Critical Reviews in Oncology/hematology·Maciej GryziakRafał Stec
Mar 7, 2021·International Journal of Molecular Sciences·Mai-Huong Thi NgoYen-Hua Huang
Apr 6, 2021·Current Hepatology Reports·Adeniji Nia, Renumathy Dhanasekaran
Apr 15, 2021·Cancer Cell International·Zahra FarzanehMaryam Farzaneh
Apr 25, 2021·Molecular Biology Reports·Magdelyn Mei-Theng WongSin-Yeang Teow
May 15, 2021·Bioscience, Biotechnology, and Biochemistry·Nam Ho JeoungHee Sung Park
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Aug 22, 2021·Current Opinion in Pharmacology·Sergio Muñoz-MartínezMaria Reig
Aug 23, 2021·Biomarker Research·Xin QingYewei Zhang
Sep 1, 2021·Journal of Hematology & Oncology·Hao ShenXiujun Cai
Apr 14, 2021·Current Drug Targets·Maria Manuela EstevinhoJoão Carvalho

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Methods Mentioned

BETA
chip
acetylation
xenografts
xenograft

Clinical Trials Mentioned

NCT03434379

Software Mentioned

GEMOX

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis