PMID: 6983591Jul 1, 1982Paper

The mechanisms of synergistic effect of antibiotics. A mechanism of synergism, cephaloridine with gentamicin on cephaloridine resistant gram negative bacilli

The Japanese journal of antibiotics
H HayashiH Nishiya

Abstract

Twelve strains out of 75 Gram negative rods, which were isolated at the clinical laboratory in the hospital, were highly resistant to cephaloridine (CER) and relatively sensitive to gentamicin (GM). Nine strains out of the 12 strains revealed synergistic effect when small doses of GM were used together with CER. A mechanism of synergistic effect on Enterobacter cloacae, 1 strain of the 9 strains, was studied through change of beta-lactamase activities. The levels of viable cell count decreased when small doses of GM were added compared with the ones obtained without the addition of GM. Similarly the levels of protein concentration and beta-lactamase activities in the sonicated component of sediment decreased, so did the level of beta-lactamase activities per cell. On the contrary, however, the beta-lactamase activities in the supernatant fluid showed no difference irrespective of the GM. Based upon the above mentioned findings, it is suggested that synergistic effect of CER and GM might be due to inhibition of protein synthesis as well as due to subsequent inhibition of beta-lactamase synthesis. This is compared with the author's previous study, in which the mechanism of synergistic effect of CER and chloramphenicol (CP) was pa...Continue Reading

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.