The Mechanistic Targets of Antifungal Agents: An Overview

Mini Reviews in Medicinal Chemistry
Tryphon K MazuS Y Ablordeppey

Abstract

Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs, which if not treated appropriately, contribute to the mortality associated with their conditions. Several studies have indicated that the majority of HIV-positive patients contract fungal infections throughout the course of their disease. Similar observations have been made regarding the increased frequency of bone marrow and organ transplants, the use of antineoplastic agents, the excessive use of antibiotics, and the prolonged use of corticosteroids among others. In addition, several pathogenic fungi have developed resistance to current drugs. Together these have conspired to spur a need for developing new treatment options for OIs. To aid this effort, this article reviews the biological targets of current and emerging drugs and agents that act through these targets for the treatment of opportunistic fungal infections.

Citations

Nov 20, 2018·Frontiers in Microbiology·Lianbao YeZhibin Shen
Dec 21, 2018·Environmental Science and Pollution Research International·Maria TrushSergiy Rogalsky
Mar 20, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Elizabeth W Hunsaker, Katherine J Franz
Oct 2, 2019·Frontiers in Microbiology·Isis Regina Grenier CapociTerezinha Inez Estivalet Svidzinski
Dec 31, 2019·Journal of Food and Drug Analysis·K J Senthil KumarSheng-Yang Wang
Dec 11, 2019·Antibiotics·Christopher R M AsquithSandro A Pereira
Sep 17, 2020·Pharmaceutics·Tábata L C LimaArnóbio Antônio da Silva-Júnior
Mar 23, 2018·International Journal of Molecular Sciences·Matthew W McCarthy, Thomas J Walsh
Mar 25, 2019·Applied and Environmental Microbiology·Asumi SugaharaKeietsu Abe
Sep 13, 2019·Antibiotics·Joana P CostaM Fernanda N N Carvalho
Sep 25, 2019·Biomolecules·Veronica Soares BrauerFausto Almeida
Dec 11, 2019·Scientific Reports·Jonas Henrique CostaTaícia Pacheco Fill
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Nathaniel YakobovHubert D Becker
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreea-Iulia PricopieOvidiu Oniga
Oct 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana BettencourtFilipe Areias
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asma A Al-HuqailAbdelfattah Z M Salem
Oct 18, 2019·Antibiotics·Iván MontenegroAlejandro Madrid
Jan 7, 2021·Natural Product Reports·Markus GresslerDirk Hoffmeister
Dec 1, 2020·Plant Physiology and Biochemistry : PPB·Vincenzo TragniCiro Leonardo Pierri
Nov 25, 2020·Antimicrobial Agents and Chemotherapy·Caroline Mota FernandesMaurizio Del Poeta
Jan 14, 2021·International Journal of Biological Macromolecules·Payal GuptaKrishna Mohan Poluri
Jan 30, 2021·Frontiers in Molecular Biosciences·Stephanie NguyenJohn B Bruning
Mar 11, 2020·Bioorganic Chemistry·Rajesh Kumar SharmaDiksha Katiyar
Mar 9, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Hong-Bin LiYi-Qun Kuang
Feb 3, 2021·Chembiochem : a European Journal of Chemical Biology·Lobna A ElsadekHendrik Luesch
Mar 27, 2021·Nature Biotechnology·Christoph B MessnerMarkus Ralser
Jan 15, 2019·Biochimica Et Biophysica Acta. Biomembranes·Elisabeth MantilTyler J Avis
Mar 12, 2021·G3 : Genes - Genomes - Genetics·Elizabeth W HunsakerKatherine J Franz
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Zubair Alam, Mohd Sajjad Ahmad Khan
Jan 3, 2018·Journal of Medicinal Chemistry·Na LiuChunquan Sheng
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang
Oct 5, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Rania Helmy Abd El-HameedSamar Said Fatahala
Aug 13, 2021·The Indian Journal of Medical Research·Rocco Luca Emanuele LiardoMarco Vacante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of the Michigan Dental Association
R D Weber
Caderno de terapêutica Labor
R V MILDER, M A JAMRA
Current Opinion in Pediatrics
T LehrnbecherS J Chanock
Expert Opinion on Pharmacotherapy
Carlos Rubio-Terrés, Santiago Grau
© 2022 Meta ULC. All rights reserved