The mechanobiology of zebrafish cardiac valve leaflet formation

Current Opinion in Cell Biology
Alessio Paolini, Salim Abdelilah-Seyfried

Abstract

Over a lifetime, rhythmic contractions of the heart provide a continuous flow of blood throughout the body. An essential morphogenetic process during cardiac development which ensures unidirectional blood flow is the formation of cardiac valves. These structures are largely composed of extracellular matrix and of endocardial cells, a specialized population of endothelial cells that line the interior of the heart and that are subjected to changing hemodynamic forces. Recent studies have significantly expanded our understanding of this morphogenetic process. They highlight the importance of the mechanobiology of cardiac valve formation and show how biophysical forces due to blood flow drive biochemical and electrical signaling required for the differentiation of cells to produce cardiac valves.

Citations

Oct 20, 2019·Development·Verónica A LombardoSalim Abdelilah-Seyfried
Mar 1, 2019·Scientific Reports·Till Joscha DemalSalim Abdelilah-Seyfried
May 2, 2020·Journal of the American College of Cardiology·Gonzalo Del Monte-NietoJason C Kovacic
Mar 15, 2021·Current Opinion in Hematology·Claudia Jasmin Rödel, Salim Abdelilah-Seyfried
Jun 21, 2021·Current Opinion in Cell Biology·Felix GunawanDidier Y R Stainier
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Dorothee Bornhorst, Salim Abdelilah-Seyfried
Oct 27, 2021·Journal of the Royal Society, Interface·Sreyashi ChakrabortyPavlos P Vlachos

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