The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice.

Scientific Reports
George W S BurwoodA L Nuttall

Abstract

The mammalian cochlea possesses unique acoustic sensitivity due to a mechanoelectrical 'amplifier', which requires the metabolic support of the cochlear lateral wall. Loud sound exposure sufficient to induce permanent hearing damage causes cochlear blood flow reduction, which may contribute to hearing loss. However, sensory epithelium involvement in the cochlear blood flow regulation pathway is not fully described. We hypothesize that genetic manipulation of the mechanoelectrical transducer complex will abolish sound induced cochlear blood flow regulation. We used salsa mice, a Chd23 mutant with no mechanoelectrical transduction, and deafness before p56. Using optical coherence tomography angiography, we measured the cochlear blood flow of salsa and wild-type mice in response to loud sound (120 dB SPL, 30 minutes low-pass filtered noise). An expected sound induced decrease in cochlear blood flow occurred in CBA/CaJ mice, but surprisingly the same sound protocol induced cochlear blood flow increases in salsa mice. Blood flow did not change in the contralateral ear. Disruption of the sympathetic nervous system partially abolished the observed wild-type blood flow decrease but not the salsa increase. Therefore sympathetic activati...Continue Reading

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Citations

Nov 13, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·So Young JungHeebeom Koo

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Methods Mentioned

BETA
restriction digest
PCR
Cochlear

Key Resources (RRID) Mentioned

IMSR_JAX
SCR_013517
AB_10015251
AB_2534017
AB_2651133
AB_2532155
SCR_003070
SCR_014325
SCR_001622

Software Mentioned

MATLAB
ImageJ
OCTA
Measure
SSADA
LabVIEW

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