The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

Neuron
Yuanquan SongYuh Nung Jan

Abstract

Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca2+-permeable non-selective cation channel, functions as an intrinsic inhibitor for axon regeneration in Drosophila. DmPiezo activation during axon regeneration induces local Ca2+ transients at the growth cone, leading to activation of nitric oxide synthase and the downstream cGMP kinase Foraging or PKG to restrict axon regrowth. Loss of DmPiezo enhances axon regeneration of sensory neurons in the peripheral and CNS. Conditional knockout of its mammalian homolog Piezo1 in vivo accelerates regeneration, while its pharmacological activation in vitro modestly reduces regeneration, suggesting the role of Piezo in inhibiting regeneration may be evolutionarily conserved. These findings provide a precedent for the involvement of mechanosensitive channels in axon regeneration and add a potential target for modulating nervous system repair.

Citations

Jul 13, 2019·Pediatric Hematology and Oncology·Tristan KnightYaddanapudi Ravindranath
Sep 20, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·David J Beech, Antreas C Kalli
Aug 23, 2019·Glia·María Velasco-EstevezGraham K Sheridan
May 2, 2020·The European Journal of Neuroscience·Chloe M HallGraham K Sheridan
Jun 3, 2020·International Journal of Molecular Sciences·Jueun RohChul-Kyu Park
Feb 23, 2020·Annual Review of Neuroscience·Peng JinYuh-Nung Jan
Jul 30, 2020·Cells·Michela Rigoni, Samuele Negro
Aug 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Wang ZhengSviatoslav N Bagriantsev
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Juan Sebastián JaraEdmund R Hollis
Mar 23, 2019·Nature Reviews. Neuroscience·Sian Lewis
Aug 28, 2019·Annual Review of Pharmacology and Toxicology·Bailong Xiao
Sep 10, 2019·F1000Research·Melissa A QuintanillaJordan R Beach
Jul 1, 2020·Annual Review of Cell and Developmental Biology·Kristian Franze
Jan 12, 2021·Frontiers in Physiology·Gerd Bicker, Michael Stern
Nov 1, 2020·International Journal of Molecular Sciences·Sara De VincentiisVittoria Raffa
Feb 22, 2021·Trends in Biochemical Sciences·Yan JiangBailong Xiao
Dec 2, 2020·Trends in Neurosciences·Philip HehlertMartin C Göpfert
Mar 24, 2021·Trends in Pharmacological Sciences·Ali MominXi Huang
Jun 22, 2021·Annual Review of Biochemistry·Marcin SzczotAlexander T Chesler
Jun 26, 2021·Scientific Reports·Giacomo CartaFederica Fregnan
Jul 9, 2021·Annual Review of Neuroscience·Ruhma Syeda
Aug 4, 2021·Advanced Healthcare Materials·Cara T MotzCheng Zhu
Jan 1, 2022·Proceedings of the National Academy of Sciences of the United States of America·Ramon Latorre, Ignacio Díaz-Franulic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Patrick C KersteinTimothy M Gomez
The Journal of Membrane Biology
C E Morris
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fangjun TangKatherine Kalil
© 2022 Meta ULC. All rights reserved